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  Optimization of OH-CEST contrast at 3T for clinical application of glucoCEST MRI

Gandhi, C., Longo, D., Anemone, A., Herz, K., Deshmane, A., Lindig, T., et al. (2018). Optimization of OH-CEST contrast at 3T for clinical application of glucoCEST MRI. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7D86-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-930A-E
Genre: Poster

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 Creators:
Gandhi, C1, 2, Author              
Longo, D, Author
Anemone, A, Author
Herz, K1, 2, Author              
Deshmane, A1, 2, Author              
Lindig, T, Author              
Bender, B, Author              
Aime, S, Author
Scheffler, K1, 2, Author              
Zaiss, M1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: A 3D snapshot CEST sequence is optimized for contrast originating from hydroxyl groups of glucose molecules. Multi-B1-multi-pH measurements allow fitting of exchange rates of four glucose hydroxyl groups, which are then used to optimize pre-saturation parameters in simulation. The optimal protocol gave highly reproducible signals in 6 healthy volunteers, and showed no contrast when tested in a brain tumor patient. This protocol provides a robust baseline for glucose injection studies.

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 Dates: 2018-06
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: GandhiLAHDLBASZ2018
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris, France
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2233 Start / End Page: - Identifier: -