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  Histoarchitectonically distinct regions of anterior cingulate show altered glutamatergic metabolism in major depressive disorder

Martens, L., von Düring, F., Colic, L., Li, S., Demenescu, L., Denzel, D., et al. (2018). Histoarchitectonically distinct regions of anterior cingulate show altered glutamatergic metabolism in major depressive disorder. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7DA0-E Version Permalink: http://hdl.handle.net/21.11116/0000-0001-92FF-B
Genre: Poster

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Martens, L1, 2, Author              
von Düring, F, Author
Colic, L, Author
Li, S, Author
Demenescu, LR, Author
Denzel, D, Author
Ristow, I, Author
Vogel, M, Author
Lison, S, Author
Speck, O, Author
Li, M, Author
Li, Meng1, 2, Author              
Walter, M1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Increasing evidence suggests a hypoglutamatergic state in major depressive disorder (MDD), however spatial- and metabolite specific abnormalities have not been fully characterized. Using short TE/TM STEAM MRS, we evaluated Glu, Gln, Gln/Glu and GABA metabolism in two histoarchitectonically distinct subdivisions of the anterior cingulate cortex (ACC). The pregenual ACC, involved in emotion processing, showed altered glutamine-glutamine cycling but not altered GABAergic metabolism in MDD, whereas no differences between patients and controls were found in the anteromedial ACC. Increased Gln/Glu in MDD in pgACC but not aMCC confirms a regionally specific role of altered glutamatergic metabolism and neuronal-glial interaction.

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 Dates: 2018-06
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: MartensvCLDDRVLSLW2018
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris, France
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1817 Start / End Page: - Identifier: -