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Abstract:
The goal of this study is to develop 3D high resolution MRF scans and partial volume analysis methods to assist detection and characterization of epileptogenic foci in patients with drug refractory epilepsy undergoing presurgical evaluation. In addition to providing quantitative T1/T2 values for tissue characterization, we hypothesize that quantitative maps also provide better sensitivity in detecting subtle epileptic lesions. To this end, high resolution T1 and T2 maps, as well as gray matter, white matter fractions maps and tissue cluster maps, were used to detect and characterize epileptic lesions that were difficult to identify from the weighted images and from conventional voxel-based post-processing analysis based on T1-weighted images.
