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  Amide chemical exchange saturation transfer at 7T: A possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients

Krikken, E., Khlebnikov, V., Zaiss, M., Jibodh, R., van Diest, P., Luijten, P., et al. (2018). Amide chemical exchange saturation transfer at 7T: A possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients. In Joint Annual Meeting ISMRM-ESMRMB 2018.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7E14-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-9390-5
Genre: Meeting Abstract

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 Creators:
Krikken, E, Author
Khlebnikov, V, Author
Zaiss, M1, 2, Author              
Jibodh, RA, Author
van Diest, PJ, Author
Luijten, PR, Author
Klomp, DWJ, Author
van Laarhoven, HWM, Author
Wijnen, JP, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Neoadjuvant chemotherapy (NAC) has an important role in the treatment of breast cancer and the need for early detection of treatment response is high. Therefore we investigated the feasibility of using APT CEST at 7T as a biomarker for this purpose. Ten lesions were included and APT signal before and after the first cycle of NAC were correlated to the pathological response. Significant differences were found in APT signal corresponding with the pathological response. These results suggest that APT CEST may be used to predict the response to NAC treatment in an early stage.

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 Dates: 2018-06
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: KrikkenKZJvLKvW2018
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris, France
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0808 Start / End Page: - Identifier: -