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  MRI-guided robotic arm (MgRA) drives optogenetic activation of the rat corpus callosum

Chen, Y., Pais Roldan, P., Chen, X., & Yu, X. (2018). MRI-guided robotic arm (MgRA) drives optogenetic activation of the rat corpus callosum. In Joint Annual Meeting ISMRM-ESMRMB 2018.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-7E35-7 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-938A-D
Genre: Meeting Abstract

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 Creators:
Chen, Y1, 2, Author           
Pais Roldan, P1, 2, Author           
Chen, X1, 2, Author           
Yu, X1, 2, Author           
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: An MRI-compatible robotic arm was developed to provide a precise fiber positioning for optogenetic fMRI of the rat brain. Corpus callosum connects two hemispheres through a thin sheet of spreading fiber bundle with only a few hundred micron thickness in the brain. This work shows that MgRA can guide fiber optic to precisely target the callosal fiber bundles. The optogenetically driven callosal axonal fiber-mediated neural activity leads to strong antidromic activation in the hemisphere with callosal neurons expressing ChR2 by fMRI.

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 Dates: 2018-06
 Publication Status: Issued
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 Identifiers: BibTex Citekey: ChenPCY2018
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris, France
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0652 Start / End Page: - Identifier: -