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  Amide chemical exchange saturation transfer at 7 T: a possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients

Krikken, E., Khlebnikov, V., Zaiss, M., Jibodh, R., van Diest, P., Luijten, P., et al. (2018). Amide chemical exchange saturation transfer at 7 T: a possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients. Breast Cancer Research, 20(51), 1-9. doi:10.1186/s13058-018-0982-2.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-7F6D-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7F6E-7
Genre: Journal Article

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Krikken, E, Author
Khlebnikov, V, Author
Zaiss, M1, 2, Author              
Jibodh, RA, Author
van Diest, PJ, Author
Luijten, PR, Author
Klomp, DWJ, Author
van Laarhoven, HWM, Author
Wijnen, JP, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Background The purpose of this work was to investigate noninvasive early detection of treatment response of breast cancer patients to neoadjuvant chemotherapy (NAC) using chemical exchange saturation transfer (CEST) measurements sensitive to amide proton transfer (APT) at 7 T. Methods CEST images were acquired in 10 tumors of nine breast cancer patients treated with NAC. APT signals in the tumor, before and after the first cycle of NAC, were quantified using a three-pool Lorentzian fit of the z-spectra in the region of interest. The changes in APT were subsequently related to pathological response after surgery defined by the Miller-Payne system. Results Significant differences (P <  0.05, unpaired Mann-Whitney test) were found in the APT signal before and after the first cycle of NAC in six out of 10 lesions, of which two showed a pathological complete response. Of the remaining four lesions, one showed a pathological complete response. No significant difference in changes of APT signal were found between the different pathological responses to NAC treatment (P > 0.05, Kruskal-Wallis test). Conclusions This preliminary study shows the feasibility of using APT CEST magnetic resonance imaging as a noninvasive biomarker to assess the effect of NAC in an early stage of NAC treatment of breast cancer patients.

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 Dates: 2018-06
 Publication Status: Published in print
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 Identifiers: DOI: 10.1186/s13058-018-0982-2
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Title: Breast Cancer Research
  Other : Breast Cancer Res.
Source Genre: Journal
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Publ. Info: London : BioMed Central Ltd.
Pages: - Volume / Issue: 20 (51) Sequence Number: - Start / End Page: 1 - 9 Identifier: ISSN: 1465-5411
CoNE: /journals/resource/110978984569491