Chronic CRH depletion from GABAergic, long-range projection neurons in the 
extended amygdala reduces dopamine release and increases anxiety

Dedic, Nina; Kühne, Claudia; Jakovcevski, Mira; Hartmann, Jakob; Genewsky, Andreas J.; Gomes, Karina S.; Anderzhanova, Elmira; Pöhlmann, Max L.; Chang, Simon; Kolarz, Adam; Vogl, Annette M.; Dine, Julien; Metzger, Michael W.; Schmid, Bianca; Almada, Rafael C.; Ressler, Kerry J.; Wotjak, Carsten T.; Grinevich, Valery; Chen, Alon; Schmidt, Mathias V.; Wurst, Wolfgang; Refojo, Damian; Deussing, Jan M.

doi:10.1038/s41593-018-0151-z

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Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Dedic, N., Kühne, C., Jakovcevski, M., Hartmann, J., Genewsky, A. J., Gomes, K. S., et al. (2018). Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. NATURE NEUROSCIENCE, 21(6), 803-807. doi:10.1038/s41593-018-0151-z.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-8BCC-D Version Permalink: https://hdl.handle.net/21.11116/0000-0001-8BCD-C

Genre: Journal Article

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Creators:
Dedic, Nina¹, Author
Kühne, Claudia¹, Author
Jakovcevski, Mira¹, Author
Hartmann, Jakob^{1, 2}, Author
Genewsky, Andreas J.¹, Author
Gomes, Karina S.^{1, 2}, Author
Anderzhanova, Elmira¹, Author
Pöhlmann, Max L.¹, Author
Chang, Simon¹, Author
Kolarz, Adam¹, Author
Vogl, Annette M.¹, Author
Dine, Julien¹, Author
Metzger, Michael W.¹, Author
Schmid, Bianca¹, Author
Almada, Rafael C.¹, Author
Ressler, Kerry J.², Author
Wotjak, Carsten T.¹, Author
Grinevich, Valery², Author
Chen, Alon¹, Author
Schmidt, Mathias V.¹, Author
Wurst, Wolfgang², AuthorRefojo, Damian^{1, 2}, Author         Deussing, Jan M.¹, Author          more..

Affiliations:
1Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294
2external, ou_persistent22

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Free keywords: VENTRAL TEGMENTAL AREA; CONDITIONED FEAR; MICE; EXPRESSION; STRESS; FOREBRAIN; MEDIATE; EXTINCTION; RECEPTOR; CIRCUITNeurosciences & Neurology;

Abstract: The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

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Language(s): eng - English

Dates: Date issued: 2018

Publication Status: Issued

Pages: 8

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Table of Contents: -

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Identifiers: ISI: 000433232600008
DOI: 10.1038/s41593-018-0151-z

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Grant ID : 01ZX1314H

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Funding organization : German Federal Ministry of Education and Research (BMBF)

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Grant ID : 2013/03445-3

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Funding organization : (FAPESP)

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Title: NATURE NEUROSCIENCE

Source Genre: Journal

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Publ. Info: NATURE PUBLISHING GROUP

Pages: - Volume / Issue: 21 (6) Sequence Number: - Start / End Page: 803 - 807 Identifier: ISSN: 1097-6256