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Schlagwörter:
VENTRAL TEGMENTAL AREA; CONDITIONED FEAR; MICE; EXPRESSION; STRESS;
FOREBRAIN; MEDIATE; EXTINCTION; RECEPTOR; CIRCUITNeurosciences & Neurology;
Zusammenfassung:
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
