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  Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains

Schuenemann, V. J., Lankapalli, A. K., Barquera, R., Nelson, E. A., Iraíz Hernández, D., Acuña Alonzo, V., et al. (2018). Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains. PLOS Neglected Tropical Diseases, 12(6): e0006447. doi:10.1371/journal.pntd.0006447.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-8BDB-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-8BDC-B
Genre: Journal Article

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 Creators:
Schuenemann, Verena J., Author
Lankapalli, Aditya Kumar1, Author              
Barquera, Rodrigo1, Author              
Nelson, Elizabeth A.1, Author              
Iraíz Hernández, Diana1, Author              
Acuña Alonzo, Víctor, Author
Bos, Kirsten I.1, Author              
Márquez Morfín, Lourdes, Author
Herbig, Alexander1, Author              
Krause, Johannes1, 2, Author              
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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 Abstract: Author summary Among the worldwide prevalent treponemal diseases syphilis is a global threat that is currently re-emerging. The origins of syphilis and other treponemal diseases are as yet unresolved and are subject to an intensive scholarly debate. Until now, assumptions on its origins and evolutionary history could only be drawn from osteological analyses of past cases and genetic analysis of contemporary T. pallidum genomes; contributions from ancient DNA are very rare and have so far failed to provide genome-level data. The ancient T. pallidum genomes presented here allow us, for the first time, to perform genome-wide comparative analyses and to assess a connection between osteological manifestations of past treponemal cases and specific T. pallidum species. Our study demonstrates the possibility of retrieving ancient T. pallidum genomes from archeological material and thereby establishes a new method that could greatly contribute to uncover the mystery regarding the origins of treponemal diseases.

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Language(s): eng - English
 Dates: 2018-06-21
 Publication Status: Published online
 Pages: 20
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1371/journal.pntd.0006447
Other: shh1014
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Title: PLOS Neglected Tropical Diseases
  Alternative Title : PLOS Neglected Tropical Diseases
Source Genre: Journal
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Publ. Info: Public Library of Science
Pages: - Volume / Issue: 12 (6) Sequence Number: e0006447 Start / End Page: - Identifier: ISSN: 1935-2735