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  Transcriptomic analysis of left-right differences in human embryonic forebrain and midbrain

De Kovel, C. G. F., Lisgo, S. N., & Francks, C. (2018). Transcriptomic analysis of left-right differences in human embryonic forebrain and midbrain. Scientific Data, 5: 180164. doi:10.1038/sdata.2018.164.

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DeKovel_Lisgo_Francks_2018.pdf (Publisher version), 639KB
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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.

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De Kovel, Carolien G. F.1, Author           
Lisgo, Steven N.2, Author
Francks, Clyde1, 3, Author           
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1Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
2Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK, ou_persistent22              
3Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              

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 Abstract: Left-right asymmetry is subtle but pervasive in the human central nervous system. This asymmetry is initiated early during development, but its mechanisms are poorly known. Forebrains and midbrains were dissected from six human embryos at Carnegie stages 15 or 16, one of which was female. The structures were divided into left and right sides, and RNA was isolated. RNA was sequenced with 100 base-pair paired ends using Illumina Hiseq 4000. After quality control, five paired brain sides were available for midbrain and forebrain. A paired analysis between left- and right sides of a given brain structure across the embryos identified left-right differences. The dataset, consisting of Fastq files and a read count table, can be further used to study early development of the human brain

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Language(s): eng - English
 Dates: 20182018-09-04
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/sdata.2018.164
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Title: Scientific Data
  Abbreviation : Sci. Data
Source Genre: Journal
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Publ. Info: London, United Kingdom : Nature Publishing Group
Pages: - Volume / Issue: 5 Sequence Number: 180164 Start / End Page: - Identifier: Other: 2052-4463
CoNE: https://pure.mpg.de/cone/journals/resource/2052-4463