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  Concurrent multisite recordings and brain imaging: a study of events related system and synaptic memory consolidation

Logothetis, N., Eschenko, O., Besserve, M., Murayama, Y., Evrard, H., & Ramirez-Villegas, J. (2018). Concurrent multisite recordings and brain imaging: a study of events related system and synaptic memory consolidation. Talk presented at AREADNE 2018: Research in Encoding And Decoding of Neural Ensembles. Santorini, Greece. 2018-06-20 - 2018-06-24.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-9417-E Version Permalink: http://hdl.handle.net/21.11116/0000-0001-942F-4
Genre: Talk

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 Creators:
Logothetis, NK1, 2, Author              
Eschenko, O1, 2, Author              
Besserve, M, Author              
Murayama, Y1, 2, Author              
Evrard, HC1, 2, Author              
Ramirez-Villegas, JF1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Experimental work in animals and humans suggests that various oscillatory patterns, including single or multiple cycle short-lasting episodes, reflect state-changes in self-organizing largescale networks. For instance, patterns like K-complexes, spindles, hippocampal sharp wave ripples, and PGO waves, are thought to reflect state-changes in networks regulating cognitive capacities, such as learning, memory encoding and consolidation, and memory-guided decision making . Although studied in detail with neurophysiological methods, the global effects of the aforementioned events on the entire brain remained elusive. The use of multishankmultichannel (MS-MC) electrical recordings of activity in different structures per se permits both the detection and the contextual identification of structure-specific neural events, for that matter also of their interrelationships. Combining MS-MC recordings with spatiotemporally resolved fMRI evidently oଏers a unique opportunity to study the cooperative patterns of a large number of brain structures either leading or responding to recorded events. In an effort to do so, we developed so-called neural event triggered fMRI (NET-fMRI), and used it to study the dynamics of the networks related to ripples and PGO events. Initial recordings in hippocampus with ripple-triggered functional magnetic resonance imaging, showed that most of the cortex is selectively activated during the ripples, whereas most diencephalic, midbrain and brainstem regions are strongly inhibited [3]. Other regions, such as the parabrachial nucleus in pons were up or down-modulated and so were the low frequency field potentials in the peri-event intervals. Analysis of the temporal alignment between the SPW and ripple components revealed well-diଏerentiated SPW-R subtypes in the CA1 LFP . Well defined PGO-subtypes were also evident in pons, with phasic events often occurring together with ripples and brief oscillations occurring exclusively in REM periods characterized by high hippocampal theta activity. The co-occurrence of ripples and PGO waves is the first evidence for a sequential occurrence of synaptic tagging and local plasticity changes potentially induced by the cholinergic PGO activity, that is related to synaptic consolidation. In the talk I will present new results related to such event interactions, and the global NET-fMRI patterns associated with them.

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 Dates: 2018-06
 Publication Status: Published in print
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Title: AREADNE 2018: Research in Encoding And Decoding of Neural Ensembles
Place of Event: Santorini, Greece
Start-/End Date: 2018-06-20 - 2018-06-24
Invited: Yes

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Title: AREADNE 2018: Research in Encoding And Decoding of Neural Ensembles
Source Genre: Proceedings
 Creator(s):
Hatsopoulos, NG, Editor
Pezaris, JS, Editor
Affiliations:
-
Publ. Info: Cambridge, MA, USA : AREADNE Foundation
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 32 Identifier: ISSN: 2155-3203