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  Microstimulation and NET-fMRI examination of the relation between the anterior insular cortex and the whole-brain activity in the macaque monkey

Smuda, J., Klein, C., Murayama, Y., Oeltermann, A., Werner, J., Steudel, T., et al. (2018). Microstimulation and NET-fMRI examination of the relation between the anterior insular cortex and the whole-brain activity in the macaque monkey. Poster presented at 11th FENS Forum of Neuroscience, Berlin, Germany.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-95C3-A Version Permalink: http://hdl.handle.net/21.11116/0000-0001-95C4-9
Genre: Poster

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 Creators:
Smuda, J1, 2, Author              
Klein, C1, 2, Author              
Murayama, Y1, 2, Author              
Oeltermann, A1, 2, Author              
Werner, J1, 2, Author              
Steudel, T1, 2, Author              
Krampe, E1, 2, Author              
Logothetis, NK1, 2, Author              
Evrard, HC1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The anterior insular cortex (AIC) is often regarded as a key “node” of the salience network that mediates the central representation and goal-directed control of homeostatic bodily states by coordinating brain networks. Given the possible role of the AIC in brain network dynamics, we combined electrophysiology and electrical microstimulation in the left and right AIC with functional magnetic resonance imaging (fMRI) to examine blood-oxygen-level-dependent (BOLD) signal changes in cortical and subcortical areas in 4 anesthetized macaque monkeys in a 7T scanner. 10-channel laminar electrodes were introduced in the ‘von Economo neuron area’ of the AIC to record ongoing spontaneous neuronal activity during two-shot echo-planar imaging with a temporal resolution of 2 seconds. Focusing on the local field potential gamma band (56-79 Hz) unilateral events were detected and used to trigger the BOLD signal, a method called ‘neural-event-triggered fMRI’ (NET-fMRI) (Logothetis et al. Nature 2012 491:547-53). The results showed markedly different patterns of whole-brain activation and deactivation for the left and right AIC. Subsequently, the laminar electrodes were replaced with single channel iridium electrodes to alternately deliver electrical microstimulation pulses (200μs biphasic charge-balanced pulses with a 100 Hz frequency) to the left and right AIC. Although the stimulations activated the same brain areas (e.g. amygdala, thalamus) the whole-brain activity following left stimulation tended to be stronger and more prevalent. These results, combined with our tract-tracing data begin to unravel the functional organization underlying the role of the AIC in functional brain networks and brainstem autonomic control regulation.

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 Dates: 2018-07
 Publication Status: Published in print
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Title: 11th FENS Forum of Neuroscience
Place of Event: Berlin, Germany
Start-/End Date: 2018-07-07 - 2018-07-11

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Title: 11th FENS Forum of Neuroscience
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 37635 Start / End Page: - Identifier: -