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  Reconstruction of the synaptic and cell type specific brain-wide organization of neuronal networks

Seetharama, M., Guest, J., Hyoungjun, P., Wendlandt, T., Strick, P., & Oberlaender, M. (2018). Reconstruction of the synaptic and cell type specific brain-wide organization of neuronal networks. Poster presented at 11th FENS Forum of Neuroscience, Berlin, Germany.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-95D5-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-95FB-C
Genre: Poster

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 Creators:
Seetharama, M, Author
Guest, J, Author
Hyoungjun, P, Author
Wendlandt, T, Author
Strick, P, Author
Oberlaender, M1, 2, Author              
Affiliations:
1Former Research Group Computational Neuroanatomy, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528698              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Delineating the organization of brain-wide neural networks across scales – from cell populations to individual synapses – has been challenging. Replication competent Rabies virus strains can potentially be applied to reveal hierarchical organization of multi-synaptic brain-wide networks. Here, we present a framework to reconstruct the cell type specific organization of whisker related networks at synaptic level. We inject the retrograde rabies virus into a single intrinsic whisker muscle and quantify the trans-synaptic spread across orders of labeling. Furthermore, reconstruction of rabies labelled morphologies provides cell type specific identification of cells within the network. This approach can potentially be applied to reveal the differences in brain-wide network organization due to pathology.

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 Dates: 2018-07
 Publication Status: Published in print
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Title: 11th FENS Forum of Neuroscience
Place of Event: Berlin, Germany
Start-/End Date: 2018-07-07 - 2018-07-11

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Title: 11th FENS Forum of Neuroscience
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 37095 Start / End Page: - Identifier: -