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  Structural neural correlates of physiological mirror activity during isometric contractions of non-dominant hand muscles

Maudrich, T., Kenville, R., Lepsien, J., Villringer, A., & Ragert, P. (2018). Structural neural correlates of physiological mirror activity during isometric contractions of non-dominant hand muscles. Scientific Reports, 8: 9178. doi:10.1038/s41598-018-27471-5.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-9668-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9AE6-C
Genre: Journal Article

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 Creators:
Maudrich, Tom1, 2, Author              
Kenville, Rouven1, 2, Author              
Lepsien, Jöran3, Author              
Villringer, Arno2, 4, 5, Author              
Ragert, Patrick1, 2, Author              
Affiliations:
1Institute of General Kinesiology and Athletics Training, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634558              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Anterior cingulate; Article; Fractional anisotropy; Gray matter; Hand muscle; Human; Human experiment; Muscle contractility; Muscle isometric contraction; Precuneus; Primary motor cortex; Statistics; Voxel based morphometry; White matter
 Abstract: Mirror Activity (MA) describes involuntarily occurring muscular activity in contralateral homologous limbs during unilateral movements. This phenomenon has not only been reported in patients with neurological disorders (i.e. Mirror Movements) but has also been observed in healthy adults referred to as physiological Mirror Activity (pMA). However, despite recent hypotheses, the underlying neural mechanisms and structural correlates of pMA still remain insufficiently described. We investigated the structural correlates of pMA during isometric contractions of hand muscles with increasing force demands on a whole-brain level by means of voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). We found significant negative correlations between individual tendencies to display pMA and grey matter volume (GMV) in the right anterior cingulate cortex (ACC) as well as fractional anisotropy (FA) of white matter (WM) tracts of left precuneus (PrC) during left (non-dominant) hand contractions. No significant structural associations for contractions of the right hand were found. Here we extend previously reported functional associations between ACC/PrC and the inhibtion of intrinsically favoured mirror-symmetrical movement tendencies to an underlying structural level. We provide novel evidence that the individual structural state of higher order motor/executive areas upstream of primary/secondary motor areas might contribute to the phenomen of pMA.

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Language(s): eng - English
 Dates: 2017-12-192018-06-042018-06-15
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-018-27471-5
PMID: 29907835
PMC: PMC6003937
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Funding organization : Max-Planck Society

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 9178 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322