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  The fusion pore, 60 years after the first cartoon.

Sharma, S., & Lindau, M. (2018). The fusion pore, 60 years after the first cartoon. FEBS Letters, 592(21), 3542-3562. doi:10.1002/1873-3468.13160.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-9C9D-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B925-3
Genre: Journal Article

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2615641.pdf (Publisher version), 864KB
 
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 Creators:
Sharma, S.1, Author              
Lindau, M.1, Author              
Affiliations:
1Research Group of Nanoscale Cell Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1832294              

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Free keywords: exocytosis; fusion pore; membrane fusion
 Abstract: Neurotransmitter release occurs in the form of quantal events by fusion of secretory vesicles with the plasma membrane, and begins with the formation of a fusion pore that has a conductance similar to that of a large ion channel or gap junction. In this review, we propose mechanisms of fusion pore formation and discuss their implications for fusion pore structure and function. Accumulating evidence indicates a direct role of soluble N-ethylmaleimide-sensitive-factor attachment receptor proteins in the opening of fusion pores. Fusion pores are likely neither protein channels nor purely lipid, but are of proteolipidic composition. Future perspectives to gain better insight into the molecular structure of fusion pores are discussed.

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Language(s): eng - English
 Dates: 2018-06-142018-11-12
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/1873-3468.13160
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Title: FEBS Letters
Source Genre: Journal
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Pages: - Volume / Issue: 592 (21) Sequence Number: - Start / End Page: 3542 - 3562 Identifier: -