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  A specific, glycomimetic Langerin ligand for human Langerhans cell targeting

Wamhoff, E.-C., Schulze, J., Bellmann, L., Rentzsch, M., Bachem, G., Fuchsberger, F. F., et al. (2019). A specific, glycomimetic Langerin ligand for human Langerhans cell targeting. ACS Central Science, 5(5), 808-820. doi:10.1021/acscentsci.9b00093.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-AAB5-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B622-9
Genre: Journal Article

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 Creators:
Wamhoff, Eike-Christian1, Author              
Schulze, Jessica1, Author              
Bellmann, Lydia, Author
Rentzsch, Mareike1, Author              
Bachem, Gunnar, Author
Fuchsberger, Felix F.1, Author              
Rademacher, Juliane2, Author
Hermann, Martin, Author
Del Frari, Barbara, Author
van Dalen, Rob, Author
Hartmann, David1, Author
van Sorge, Nina, Author
Seitz, Oliver, Author
Stoitzner, Patrizia, Author
Rademacher, Christoph1, Author              
Affiliations:
1Christoph Rademacher, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863300              
2Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, Potsdam-Golm Science Park, Am Mühlenberg 1 OT Golm, 14476 Potsdam, DE, ou_1863285              

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 Abstract: Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines. Importantly, the induction of protective T cell immunity by these vaccines requires the efficient and specific delivery of both tumor-associated antigens and adjuvants. Langerhans cells uniquely express Langerin (CD207), an endocytic C-type lectin receptor. Here, we report the discovery of a specific, glycomimetic Langerin ligand employing a heparin-inspired design strategy that integrated NMR spectroscopy and molecular docking. The conjugation of these glycomimetics to liposomes enabled the specific and efficient targeting of Langerhans cells in the human skin. This delivery platform provides superior versatility and scalability over antibody-based approaches and thus addresses current limitations of dendritic cell-based immunotherapies.

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Language(s): eng - English
 Dates: 2019-05-102019
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/acscentsci.9b00093
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Title: ACS Central Science
  Other : ACS Cent. Sci.
Source Genre: Journal
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Publ. Info: Washington : American Chemical Society
Pages: - Volume / Issue: 5 (5) Sequence Number: - Start / End Page: 808 - 820 Identifier: ISSN: 2374-7951

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Title: bioRxiv
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: DOI: 10.1101/286021