English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 DetailsSummary
  A specific, glycomimetic Langerin ligand for human Langerhans cell targeting

Wamhoff, E.-C., Schulze, J., Bellmann, L., Bachem, G., Fuchsberger, F. F., Rademacher, J., et al. (2018). A specific, glycomimetic Langerin ligand for human Langerhans cell targeting. bioRxiv. doi:10.1101/286021.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0001-AAB5-3 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-AAB6-2
Genre: Journal Article

Files

show Files
hide Files
:
Author Manuscript.pdf (Preprint), 676KB
 
File Permalink:
-
Name:
Author Manuscript.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Colloids and Interfaces, MTKG; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
The copyright holder for this preprint is the author/funder. All rights reserved. No reuse allowed without permission.
License:
-

Locators

show

Creators

show
hide
 Creators:
Wamhoff, Eike-Christian1, Author           
Schulze, Jessica1, Author           
Bellmann, Lydia, Author
Bachem, Gunnar, Author
Fuchsberger, Felix F.1, Author           
Rademacher, Juliane2, Author
Hermann, Martin, Author
Del Frari, Barbara, Author
van Dalen, Rob, Author
Hartmann, David1, Author
van Sorge, Nina, Author
Seitz, Oliver, Author
Stoitzner, Patrizia, Author
Rademacher, Christoph1, Author           
Affiliations:
1Christoph Rademacher, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863300              
2Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, Potsdam-Golm Science Park, Am Mühlenberg 1 OT Golm, 14476 Potsdam, DE, ou_1863285              

Content

show
hide
Free keywords: -
 Abstract: Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines. Importantly, the induction of protective T cell immunity by these vaccines requires the efficient and specific delivery of both tumor-associated antigens and adjuvants. Langerhans cells uniquely express Langerin (CD207), an endocytic C-type lectin receptor. Here, we report the discovery of a specific, glycomimetic Langerin ligand employing a heparin-inspired design strategy that integrated NMR spectroscopy and molecular docking. The conjugation of these glycomimetics to liposomes enabled the specific and efficient targeting of Langerhans cells in the human skin. This delivery platform provides superior versatility and scalability over antibody-based approaches and thus addresses current limitations of dendritic cell-based immunotherapies.

Details

show
hide
Language(s):
 Dates: 2018-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: URI: http://biorxiv.org/content/early/2018/03/31/286021.abstract
DOI: 10.1101/286021
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: bioRxiv
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: -