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  Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells

van Dalen, R., De La Cruz Diaz, J. S., Rumpret, M., Fuchsberger, F. F., van Teijlingen, N. H., Hanske, J., et al. (2017). Staphylococcus aureus wall teichoic acid is a pathogen-associated molecular pattern that is recognized by langerin (CD207) on skin Langerhans cells. bioRxiv. doi:10.1101/238469.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-AAB0-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-F5C5-9
Genre: Journal Article

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van Dalen, Rob, Author
De La Cruz Diaz, Jacinto S., Author
Rumpret, Matevz, Author
Fuchsberger, Felix F.1, Author              
van Teijlingen, Nienke H., Author
Hanske, Jonas1, Author              
Rademacher, Christoph1, Author              
Geijtenbeek, Teunis B. H., Author
van Strip, Jos A. G., Author
Weidenmaier, Christopher, Author
Peschel, Andreas, Author
Kaplan, Daniel H., Author
van Sorge, Nina M., Author
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1Christoph Rademacher, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863300              

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 Abstract: Staphylococcus aureus is a major cause of skin and soft tissue infections and aggravator of the inflammatory skin disease atopic dermatitis (AD). Langerhans cells (LCs) initiate a Th17 response upon exposure to S. aureus, which contributes to host defense but also to AD pathogenesis. However, the molecular mechanisms underlying the unique pro-inflammatory capacities of S. aureus remain unclear. We demonstrate that human LCs directly interact with S. aureus through the pattern-recognition receptor langerin (CD207), which specifically recognizes the conserved β-N-acetylglucosamine (GlcNAc) modifications of wall teichoic acid (WTA) that are not expressed by other staphylococcal species. The WTA glycoprofile strongly influences the production of Th1- and Th17-polarizing cytokines by LCs. Specifically, β-GlcNAc activates LCs, whereas co-decoration of WTA with α-GlcNAc through the enzyme TarM, uniformly present in the AD-associated CC1 lineage, attenuates LC immune activation. Our findings provide important mechanistic insights into the role of S. aureus in inflammatory skin disease.

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 Dates: 2017-12-22
 Publication Status: Published in print
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Title: bioRxiv
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