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  Direct Imaging of Distinct Vascular Elements Detected by BOLD and Iron Oxide Based Blood Volume Using High Resolution fMRI of the Rodent Whisker Barrel

Yu, X., Porter, B., Dodd, S., Silva, A., & Koretsky, A. (2012). Direct Imaging of Distinct Vascular Elements Detected by BOLD and Iron Oxide Based Blood Volume Using High Resolution fMRI of the Rodent Whisker Barrel. Poster presented at 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.

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Yu, X1, Author              
Porter, B, Author
Dodd, S, Author
Silva, A, Author
Koretsky, A, Author
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1External Organizations, ou_persistent22              

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 Abstract: Direct characterization of the intracortical changes in vascular elements eliciting BOLD and CBV remains challenging. We measured BOLD and iron oxide based CBV in layer IV/V of the barrel cortex after whisker pad stimulation at high temporal (100msec) and spatial resolutions (150 x150µm) using EPI and fast gradient-echo MRI. Low intensity EPI voxels corresponded to activated BOLD voxels and were attributed to venules. Voxels activated using BOLD were non-overlapping with CBV voxels. Fast activations (<500msec) and distinct locations from BOLD voxels led us to attribute these CBV voxels primarily to penetrating arterioles known to vasodilate during increased neural activity.

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 Dates: 2012-05
 Publication Status: Published in print
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Title: 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012)
Place of Event: Melbourne, Australia
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Title: 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2202 Start / End Page: - Identifier: -