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  Diffusion in the extra-cellular space of the rat cerebral cortex probed by MRI and direct infusion of contrast agents

Hagberg, G., Mamedov, I., Power, A., Beyerlein, M., Merkle, H., Angelovski, G., et al. (2012). Diffusion in the extra-cellular space of the rat cerebral cortex probed by MRI and direct infusion of contrast agents. Poster presented at 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-9F34-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-9F38-E
Genre: Poster

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 Creators:
Hagberg, G1, 2, Author              
Mamedov, I2, 3, Author              
Power, A2, 3, Author              
Beyerlein, M2, 3, Author              
Merkle, H, Author              
Angelovski, G2, 3, Author              
Logothetis, NK2, 3, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Measurements of the diffusion properties of substances in the cerebral extra-cellular space (ECS) can be used to study drug delivery/clearance and brain tissue structure. Currently used methods have high sensitivity, but are limited to single spatial points or are performed post mortem, or has a limited depth penetration. Here we explore the use of MRI during direct infusion of T1 relaxating agents and mathematical modelling for investigating ECS diffusion.

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 Dates: 2012-05
 Publication Status: Published in print
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Title: 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012)
Place of Event: Melbourne, Australia
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Title: 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1841 Start / End Page: - Identifier: -