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  The use of Hoechst dyes for DNA staining and beyond.

Bucevicius, J., Lukinavicius, G., & Gerasimaite, R. (2018). The use of Hoechst dyes for DNA staining and beyond. Chemosensors, 6(2): 18. doi:10.3390/chemosensors6020018.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-A4FE-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3D8A-E
Genre: Journal Article

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2616275.pdf (Publisher version), 18MB
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 Creators:
Bucevicius, J.1, Author              
Lukinavicius, G.1, Author              
Gerasimaite, R.2, Author              
Affiliations:
1Laboratory of Chromatin Labeling and Imaging, Max Planck Institute for Biophysical Chemistry, Max Planck Society, ou_2616691              
2Department of Cellular Logistics, MPI for Biophysical Chemistry, Max Planck Society, ou_578574              

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Free keywords: fluorescent probes; biosensors; fluorescent indicators; DNA staining; protein labelling; optical microscopy; proteomics; living cells
 Abstract: Hoechst dyes are among the most popular fluorophores used to stain DNA in living and fixed cells. Moreover, their high affinity and specificity towards DNA make Hoechst dyes excellent targeting moieties, which can be conjugated to various other molecules in order to tether them to DNA. The recent developments in the fields of microscopy and flow cytometry have sparked interest in such composite molecules, whose applications range from investigating nucleus microenvironment to drug delivery into tumours. Here we provide an overview of the properties of Hoechst dyes and discuss recent developments in Hoechst-based composite probes.

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Language(s): eng - English
 Dates: 2018-04-18
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.3390/chemosensors6020018
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Title: Chemosensors
Source Genre: Journal
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Pages: 12 Volume / Issue: 6 (2) Sequence Number: 18 Start / End Page: - Identifier: -