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  Mathematical Athematical Modeling of Neurochemical Responses to Alcohol

Noori, H. (2012). Mathematical Athematical Modeling of Neurochemical Responses to Alcohol. Alcoholism: Clinical and Experimental Research, 36(Supplement 2), 20A.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-A9E6-D Version Permalink: http://hdl.handle.net/21.11116/0000-0001-A9E7-C
Genre: Meeting Abstract

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 Creators:
Noori, HR1, Author              
Affiliations:
1Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, ou_persistent22              

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 Abstract: A variety of neuropharmacological studies including lesions, microinjections and in vivo microdialysis experiment have already been applied to identify brain regions and neurochemical systems that are involved in mediating the reinforcing effects of alcohol. In the present study, we introduce a novel mathematical model to investigate the global effects of acute ethanol administration on the extracellular concentrations of neurotransmitters in adult rats. The model describes the spatiotemporal interactions of different transmitter systems, particularly aminoacids, monoamines and acetylcholine within an anatomical neurocircuitry, in constant environment and provides ranges of alterations of the local transmitter concentrations due to the administration of different doses of ethanol. In general, the outcome of the present mathematical model is a global mapping of temporal transmitter alterations respective to a stable baseline concentration. In addition to the ability of this in silico method to simulate in vivo microdialysis measurements, it provides an efficient framework to study ethanol-induced transmitter alterations in brain regions that are outside the scope of conventional techniques.

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 Dates: 2012-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/j.1530-0277.2012.01917.x
 Degree: -

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Title: 16th World Congress of the International Society for Biomedical Research on Alcoholism (ISBRA 2012)
Place of Event: Sapporo, Japan
Start-/End Date: 2012-09-08 - 2012-09-12

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Title: Alcoholism: Clinical and Experimental Research
Source Genre: Journal
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Publ. Info: Baltimore, Md., etc. : Lippincott Williams & Wilkins, etc.
Pages: - Volume / Issue: 36 (Supplement 2) Sequence Number: - Start / End Page: 20A Identifier: ISSN: 0145-6008
CoNE: https://pure.mpg.de/cone/journals/resource/954925473408