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  Selective Methylation of Arenes: A Radical C−H Functionalization/Cross‐Coupling Sequence

Serpier, F., Pan, F., Ham, W.-S., Jacq, J., Genicot, C., & Ritter, T. (2018). Selective Methylation of Arenes: A Radical C−H Functionalization/Cross‐Coupling Sequence. Angewandte Chemie International Edition, 57(33), 10697-10701. doi:10.1002/anie.201804628.

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Supporting Information (Supplementary material), 11MB
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 Creators:
Serpier, Fabien1, Author              
Pan, Fei1, Author              
Ham, Won-Seok1, 2, Author              
Jacq, Jérôme3, Author
Genicot, Christophe3, Author
Ritter, Tobias1, 2, Author              
Affiliations:
1Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              
2Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA, ou_persistent22              
3Global Chemistry, UCB Medicines, UCB BiopharmaBraine-L'Alleud, Belgium, ou_persistent22              

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Free keywords: arenes; C-H activation; cross-coupling; methylation; nickel
 Abstract: A selective, nonchelation‐assisted methylation of arenes has been developed. The overall transformation, which combines a C−H functionalization reaction with a nickel‐catalyzed cross‐coupling, offers rapid access to methylated arenes with high para selectivity. The reaction is amenable to late‐stage methylation of small‐molecule pharmaceuticals.

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Language(s): eng - English
 Dates: 2018-04-202018-06-122018-08-13
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201804628
 Degree: -

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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie, International Edition
  Other : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 57 (33) Sequence Number: - Start / End Page: 10697 - 10701 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851