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  Chromatin remodeling BAF155 subunit regulates the genesis of basal progenitors in developing cortex.

Narayanan, R., Pham, L., Kerimoglu, C., Watanabe, T., Hernandez, R. C., Sokpor, G., et al. (2018). Chromatin remodeling BAF155 subunit regulates the genesis of basal progenitors in developing cortex. iSience, 4, 109-126. doi:10.1016/j.isci.2018.05.014.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-AE6A-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-AE74-9
Genre: Journal Article

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 Creators:
Narayanan, R., Author
Pham, L., Author
Kerimoglu, C., Author
Watanabe, T.1, Author              
Hernandez, R. C., Author
Sokpor, G., Author
Ulmke, P. A., Author
Kiszka, K. A., Author
Tonchev, A. B.2, Author              
Rosenbusch, J., Author
Seong, R. H., Author
Teichmann, U.3, Author              
Frahm, J.1, Author              
Fischer, A., Author
Bonn, S., Author
Stoykova, A.2, Author              
Staiger, J. F., Author
Tuoc, T., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              
2Research Group of Molecular Developmental Neurobiology, MPI for biophysical chemistry, Max Planck Society, ou_578587              
3Animal Facility, MPI for Biophysical Chemistry, Max Planck Society, ou_2355695              

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 Abstract: The abundance of basal progenitors (BPs), basal radial glia progenitors (bRGs) and basal intermediate progenitors (bIPs), in primate brain has been correlated to the high degree of cortical folding. Here we examined the role of BAF155, a subunit of the chromatin remodeling BAF complex, in generation of cortical progenitor heterogeneity. The conditional deletion of BAF155 led to diminished bIP pool and increased number of bRGs, due to delamination of apical RGs. We found that BAF155 is required for normal activity of neurogenic transcription factor PAX6, thus controlling the expression of genes that are involved in bIP specification, cell-cell interaction, and establishment of adherens junction. In a PAX6-dependent manner, BAF155 regulates the expression of the CDC42 effector protein CEP4, thereby controlling progenitor delamination. Furthermore, BAF155-dependent chromatin remodeling seems to exert a specific role in the genesis of BPs through the regulation of human RG-specific genes (such as Foxn4) that possibly acquired evolutionary significance.

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Language(s): eng - English
 Dates: 2018-05-232018-06-29
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.isci.2018.05.014
 Degree: -

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Title: iSience
Source Genre: Journal
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Pages: - Volume / Issue: 4 Sequence Number: - Start / End Page: 109 - 126 Identifier: -