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  An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12.

Keasar, C., McGuffin, L. J., Wallner, B., Chopra, G., Adhikari, B., Bhattacharya, D., et al. (2018). An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12. Scientific Reports, 8: 9938. doi:10.1038/s41598-018-26812-8.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-AF57-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-74B0-3
Genre: Journal Article

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 Creators:
Keasar, C., Author
McGuffin, L. J., Author
Wallner, B., Author
Chopra, G., Author
Adhikari, B., Author
Bhattacharya, D., Author
Blake, L., Author
Bortot, L. O., Author
Cao, R., Author
Dhanasekaran, B. K., Author
Dimas, I., Author
Faccioli, R. A., Author
Faraggi, E., Author
Ganzynkowicz, R., Author
Ghosh, S., Author
Ghosh, S., Author
Giełdoń, A., Author
Golon, L., Author
He, Y., Author
Heo, L., Author
Hou, J., AuthorKhan, M., AuthorKhatib, F., AuthorKhoury, G. A., AuthorKieslich, C., AuthorKim, D. E., AuthorKrupa, P., AuthorLee, G. R., AuthorLi, H., AuthorLi, J., AuthorLipska, A., AuthorLiwo, A., AuthorMaghrabi, A. H. A., AuthorMirdita, M.1, Author              Mirzaei, S., AuthorMozolewska, M. A., AuthorOnel, M., AuthorOvchinnikov, S., AuthorShah, A., AuthorShah, U., AuthorSidi, T., AuthorSieradzan, A. K., AuthorŚlusarz, M., AuthorŚlusarz, R., AuthorSmadbeck, J., AuthorTamamis, P., AuthorTrieber, N., AuthorWirecki, T., AuthorYin, Y., AuthorZhang, Y., AuthorBacardit, J., AuthorBaranowski, M., AuthorChapman, N., AuthorCooper, S., AuthorDefelicibus, A., AuthorFlatten, J., AuthorKoepnick, B., AuthorPopović, Z., AuthorZaborowski, B., AuthorBaker, D., AuthorCheng, J., AuthorCzaplewski, C., AuthorDelbem, A. C. B., AuthorFloudas, C., AuthorKloczkowski, A., AuthorOłdziej, S., AuthorLevitt, M., AuthorScheraga, H., AuthorSeok, C., AuthorSöding, J.1, Author              Vishveshwara, S., AuthorXu, D., AuthorCrivelli, S. N., Author more..
Affiliations:
1Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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 Abstract: Every two years groups worldwide participate in the Critical Assessment of Protein Structure Prediction (CASP) experiment to blindly test the strengths and weaknesses of their computational methods. CASP has significantly advanced the field but many hurdles still remain, which may require new ideas and collaborations. In 2012 a web-based effort called WeFold, was initiated to promote collaboration within the CASP community and attract researchers from other fields to contribute new ideas to CASP. Members of the WeFold coopetition (cooperation and competition) participated in CASP as individual teams, but also shared components of their methods to create hybrid pipelines and actively contributed to this effort. We assert that the scale and diversity of integrative prediction pipelines could not have been achieved by any individual lab or even by any collaboration among a few partners. The models contributed by the participating groups and generated by the pipelines are publicly available at the WeFold website providing a wealth of data that remains to be tapped. Here, we analyze the results of the 2014 and 2016 pipelines showing improvements according to the CASP assessment as well as areas that require further adjustments and research.

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Language(s): eng - English
 Dates: 2018-07-02
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-018-26812-8
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Title: Scientific Reports
Source Genre: Journal
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Pages: 18 Volume / Issue: 8 Sequence Number: 9938 Start / End Page: - Identifier: -