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  Substantial changes in synaptic firing frequencies induced by glial ATP hysteresis

Noori, H. (2011). Substantial changes in synaptic firing frequencies induced by glial ATP hysteresis. Biosystems, 105(3), 238-242. doi:10.1016/j.biosystems.2011.05.009.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-B1E5-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-B1E6-3
Genre: Journal Article

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Noori, HR1, Author              
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1IWR, University of Heidelberg, ou_persistent22              

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 Abstract: Recent experimental studies strongly suggest the influence of glial purinergic transmission in the modulation of synaptic dynamics. By releasing adenosine triphosphate (ATP), which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission. The delayed multi-step feedback of the glial ATP with the neuron suggests the existence of a discrete hysteresis phenomena. By integration of this hysteretic behavior into a delayed leaky integrate-and-fire model for the tripartite synapses, a significant sensitivity of the pre- and postsynaptic firing frequency patterns to the adenosine feedback-delays is observed that might be of importance for adenosine-related neurological deficits, such as sleep disorders.

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 Dates: 2011-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.biosystems.2011.05.009
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Title: Biosystems
  Other : Biosystems [Elektronische Ressource] : Journal of Biological and Information Processing Sciences
Source Genre: Journal
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Publ. Info: Ireland, etc. : Elsevier
Pages: - Volume / Issue: 105 (3) Sequence Number: - Start / End Page: 238 - 242 Identifier: ISSN: 0303-2647
CoNE: https://pure.mpg.de/cone/journals/resource/954925510418