English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Substantial changes in synaptic firing frequencies induced by glial ATP hysteresis

Noori, H. (2011). Substantial changes in synaptic firing frequencies induced by glial ATP hysteresis. Biosystems, 105(3), 238-242. doi:10.1016/j.biosystems.2011.05.009.

Item is

Files

show Files

Locators

show
hide
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Noori, HR1, Author           
Affiliations:
1IWR, University of Heidelberg, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Recent experimental studies strongly suggest the influence of glial purinergic transmission in the modulation of synaptic dynamics. By releasing adenosine triphosphate (ATP), which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission. The delayed multi-step feedback of the glial ATP with the neuron suggests the existence of a discrete hysteresis phenomena. By integration of this hysteretic behavior into a delayed leaky integrate-and-fire model for the tripartite synapses, a significant sensitivity of the pre- and postsynaptic firing frequency patterns to the adenosine feedback-delays is observed that might be of importance for adenosine-related neurological deficits, such as sleep disorders.

Details

show
hide
Language(s):
 Dates: 2011-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.biosystems.2011.05.009
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Biosystems
  Other : Biosystems [Elektronische Ressource] : Journal of Biological and Information Processing Sciences
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Ireland, etc. : Elsevier
Pages: - Volume / Issue: 105 (3) Sequence Number: - Start / End Page: 238 - 242 Identifier: ISSN: 0303-2647
CoNE: https://pure.mpg.de/cone/journals/resource/954925510418