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  The impact of the glial spatial buffering on the K+ Nernst potential

Noori, H. (2011). The impact of the glial spatial buffering on the K+ Nernst potential. Cognitive Neurodynamics, 5(3), 285-291. doi:10.1007/s11571-011-9165-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-B1E9-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-51FD-6
Genre: Journal Article

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Noori, HR1, Author              
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1Interdisciplinary Center for Scientific Computing, University of Heidelberg, ou_persistent22              

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 Abstract: Astrocytes play a critical role in CNS metabolism, regulation of volume and ion homeostasis of the interstitial space. Of special relevance is their clearance of K+ that is released by active neurons into the extracellular space. Mathematical analysis of a modified Nernst equation for the electrochemical equilibrium of neuronal plasma membranes, suggests that K+ uptake by glial cells is not only relevant during neuronal activity but also has a non-neglectable impact on the basic electrical membrane properties, specifically the resting membrane potential, of neurons and might be clinically valuable as a factor in the genetics and epigenetics of the epilepsy and tuberous sclerosis complex.

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 Dates: 2011-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/s11571-011-9165-x
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Title: Cognitive Neurodynamics
Source Genre: Journal
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Pages: - Volume / Issue: 5 (3) Sequence Number: - Start / End Page: 285 - 291 Identifier: -