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  Molecular conformation and solvation of oligo(ethylene glycol) terminated self-assembled monolayers and their resistance to protein adsorption

Wang, R., Kreuzer, H., & Grunze, M. (1997). Molecular conformation and solvation of oligo(ethylene glycol) terminated self-assembled monolayers and their resistance to protein adsorption. The Journal of Physical Chemistry B, 101(47), 9767-9773. doi:10.1021/jp9716952.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-B35A-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-B35B-F
Genre: Journal Article

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JPhysChemB_101_1997_9767.pdf (Any fulltext), 201KB
 
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 Creators:
Wang, R.L.C., Author
Kreuzer, H.J., Author
Grunze, M.1, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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 Abstract: We study the interaction of water with oligo(ethylene glycol) (OEG)-terminated alkane thiolate self-assembled monolayers (SAMs) in the helical and the planar “all-trans” form with ab initio methods to determine the stability and density distribution in water clusters as a function of molecular conformation. We find that the amphiphilic behavior of the OEG moieties depends on their molecular conformation and that the energetics of water adsorption is dominated by electrostatic interactions. The SAM surface of helical OEG provides a template for water nucleation, whereas water is not stable on a surface of planar OEG strands. These results suggest that protein resistance of OEG-terminated self-assembled monolayers is a consequence of the stability of the interfacial water layer, which prevents direct contact between the surface and the protein.

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Language(s): eng - English
 Dates: 1997-08-201997-05-211997-08-201997
 Publication Status: Issued
 Pages: 7
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 Rev. Type: Peer
 Identifiers: DOI: 10.1021/jp9716952
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Title: The Journal of Physical Chemistry B
  Other : J. Phys. Chem. B
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Chemical Society
Pages: - Volume / Issue: 101 (47) Sequence Number: - Start / End Page: 9767 - 9773 Identifier: ISSN: 1520-6106
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000293370_1