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  Transcranial direct current stimulation (tDCS) facilitates verb learning by altering effective connectivity in the healthy brain

Fiori, V., Kunz, L., Kuhnke, P., Marangolo, P., & Hartwigsen, G. (2018). Transcranial direct current stimulation (tDCS) facilitates verb learning by altering effective connectivity in the healthy brain. NeuroImage, 181, 550-559. doi:10.1016/j.neuroimage.2018.07.040.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-B67F-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9A7F-2
Genre: Journal Article

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 Creators:
Fiori, Valentina1, Author
Kunz, Lisa2, Author              
Kuhnke, Philipp2, Author              
Marangolo, Paola1, 3, Author
Hartwigsen, Gesa2, Author              
Affiliations:
1IRCCS: Scientific Institute for Research and Healthcare, Rome, Italy, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3Università degli Studi di Napoli Federico II, Italy, ou_persistent22              

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Free keywords: Functional magnetic resonance imaging; Inferior frontal gyrus; Broca’s area; Neuromodulation; Language learning
 Abstract: Recent studies have shown that the left inferior frontal gyrus (IFG) plays a key role in language learning. Facilitatory stimulation over this region by means of anodal transcranial direct current stimulation (tDCS) can modulate linguistic abilities in healthy individuals and improve language performance in patients with post-stroke aphasia. Neuroimaging studies in healthy participants have suggested that anodal tDCS decreases task-related activity at the stimulated site when applied during different language tasks, and changes resting-state connectivity in a larger network of areas associated with language processing. However, to date, the neural correlates of the potential beneficial effects of tDCS on verb learning remain unclear. The current study investigated how anodal tDCS during verb learning modulates task-related activity and effective connectivity in the healthy language network. To this end, we combined a verb learning paradigm during functional neuroimaging with simultaneous tDCS over the left IFG in healthy human volunteers. We found that, relative to sham stimulation, anodal tDCS significantly decreased task-related activity at the stimulated left IFG and in the right homologue. Effective connectivity analysis showed that anodal tDCS significantly decreased task-related functional coupling between the left IFG and the right insula. Importantly, the individual decrease in connectivity was significantly correlated with the individual behavioural improvement during anodal tDCS. These results demonstrate, for the first time, that the behavioural improvements induced by anodal tDCS might be related to an overall decrease in processing effort both with respect to task-related activity and effective connectivity within a large language network.

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Language(s): eng - English
 Dates: 2018-07-152018-04-052018-07-162018-07-172018-11-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.07.040
PMID: 30030198
Other: Epub 2018
 Degree: -

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Funding organization : Max Planck Society
Project name : -
Grant ID : HA-6314/3-1 ; HA 6314/4-1
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 181 Sequence Number: - Start / End Page: 550 - 559 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166