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  Genetic diversity of the HLA system in human populations from the Sierra (Andean), Oriente (Amazonian) and Costa (Coastal) regions of Ecuador

Galarza, J. M., Barquera, R., Álvarez, A. M. T., Zaragoza, H., I., D., Sevilla, G. P., et al. (2018). Genetic diversity of the HLA system in human populations from the Sierra (Andean), Oriente (Amazonian) and Costa (Coastal) regions of Ecuador. Human Immunology, 79(9), 639-650. doi:10.1016/j.humimm.2018.06.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-B67B-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-959E-3
Genre: Journal Article

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 Creators:
Galarza, Juan M., Author
Barquera, Rodrigo1, Author              
Álvarez, Ana M. Tito, Author
Zaragoza, Hernández, Author
I., Diana, Author
Sevilla, Gabriela Peralta, Author
Tamayo, Andrea, Author
Pérez, Mariel, Author
Dávila, David, Author
Birnberg, Lotty, Author
Alonzo, Víctor Acuña, Author
Krause, Johannes1, 2, Author              
Grijalva, Marcelo, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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Free keywords: HLA, Ecuador, Population immunogenetics, Biological diversity, Mixed ancestry populations, MHC
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in a total of 1101 Ecuadorian individuals from three regions of the country, the Coastal region, the Andean region, and the Amazonian region, to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent HLA haplotypes with significant linkage disequilibrium in those populations are HLA-A*24∼B*35∼DRB1*04∼DQB1*03:02, A*02∼B*35∼DRB1*04∼DQB1*03:02, A*24∼B*35∼DRB1*14∼DQB1*03:01, A*02∼B*35∼DRB1*14∼DQB1*03:01 and A*02∼B*40:02∼DRB1*04∼DQB1*03:02. The only non-Native American haplotype with frequency >1% shared by all groups was A*29∼B*44∼DRB1*07∼DQB1*02. Admixture estimates obtained by a maximum likelihood method using HLA-B as genetic estimator revealed that the main genetic components for this sample of mixed-ancestry Ecuadorians are Native American (ranging from 52.86% to 63.83%) and European (from 28.95% to 46.54%), while an African genetic component was only apparent in the Coastal region (18.19%). Our findings provide a starting point for the study of population immunogenetics of Ecuadorian populations.

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 Dates: 2018-06-132018-09
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: Other: shh1031
DOI: 10.1016/j.humimm.2018.06.004
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: 79 (9) Sequence Number: - Start / End Page: 639 - 650 Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912