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  On the importance of precise electrode placement for targeted transcranial electric stimulation

Opitz, A., Yeagle, E., Thielscher, A., Schroeder, C., Mehta, A., & Milham, M. (2018). On the importance of precise electrode placement for targeted transcranial electric stimulation. NeuroImage, 181, 560-567. doi:10.1016/j.neuroimage.2018.07.027.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-B71C-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-EA97-D
Genre: Journal Article

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Opitz, A, Author
Yeagle, E, Author
Thielscher, A1, Author              
Schroeder, C, Author
Mehta, AD, Author
Milham, MP, Author
Affiliations:
1Danish Research Center for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, ou_persistent22              

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 Abstract: Transcranial electric stimulation (TES) is an increasingly popular method for non-invasive modulation of brain activity and a potential treatment for neuropsychiatric disorders. However, there are concerns about the reliability of its application because of variability in TES-induced intracranial electric fields across individuals. While realistic computational models offer can help to alleviate these concerns, their direct empirical validation is sparse, and their practical implications are not always clear. In this study, we combine direct intracranial measurements of electric fields generated by TES in surgical epilepsy patients with computational modeling. First, we directly validate the computational models and identify key parameters needed for accurate model predictions. Second, we derive practical guidelines for a reliable application of TES in terms of the precision of electrode placement needed to achieve a desired electric field distribution. Based on our results, we recommend electrode placement accuracy to be < 1 cm for a reliable application of TES across sessions.

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 Dates: 2018-072018-11
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2018.07.027
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 181 Sequence Number: - Start / End Page: 560 - 567 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166