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  Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish

Mokalled, M. H., Patra, C., Dickson, A. L., Endo, T., Stainier, D. Y., & Poss, K. D. (2016). Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. SCIENCE, 354(6312), 630-634. doi:10.1126/science.aaf2679.

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Genre: Journal Article

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 Creators:
Mokalled, Mayssa H., Author
Patra, Chinmoy1, Author           
Dickson, Amy L., Author
Endo, Toyokazu, Author
Stainier, Didier Y.R.1, Author           
Poss, Kenneth D., Author
Affiliations:
1Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591697              

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Free keywords: TISSUE GROWTH-FACTOR; TRAUMATIC BRAIN-INJURY; ADULT ZEBRAFISH; ASTROCYTES; CELLS; SCAR; RATScience & Technology - Other Topics;
 Abstract: Unlike mammals, zebrafish efficiently regenerate functional nervous system tissue after major spinal cord injury. Whereas glial scarring presents a roadblock for mammalian spinal cord repair, glial cells in zebrafish form a bridge across severed spinal cord tissue and facilitate regeneration. We performed a genome-wide profiling screen for secreted factors that are up-regulated during zebrafish spinal cord regeneration. We found that connective tissue growth factor a (ctgfa) is induced in and around glial cells that participate in initial bridging events. Mutations in ctgfa disrupted spinal cord repair, and transgenic ctgfa overexpression or local delivery of human CTGF recombinant protein accelerated bridging and functional regeneration. Our study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000386869800052
DOI: 10.1126/science.aaf2679
 Degree: -

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Title: SCIENCE
Source Genre: Journal
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Publ. Info: 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA : AMER ASSOC ADVANCEMENT SCIENCE
Pages: - Volume / Issue: 354 (6312) Sequence Number: - Start / End Page: 630 - 634 Identifier: ISSN: 0036-8075