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  Adaptation of the cerebrocortical circulation to carotid artery occlusion involves blood flow redistribution between cortical regions and is independent of eNOS

Polycarpou, A., Hricisak, L., Iring, A., Safar, D., Ruisanchez, E., Horvath, B., et al. (2016). Adaptation of the cerebrocortical circulation to carotid artery occlusion involves blood flow redistribution between cortical regions and is independent of eNOS. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 311(4), H972-H980. doi:10.1152/ajpheart.00197.2016.

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 Creators:
Polycarpou, Andreas, Author
Hricisak, Laszlo, Author
Iring, Andras1, Author              
Safar, Daniel, Author
Ruisanchez, Eva, Author
Horvath, Bela, Author
Sandor, Peter, Author
Benyo, Zoltan, Author
Affiliations:
1Pharmacology, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591696              

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Free keywords: NITRIC-OXIDE SYNTHASE; FOCAL CEREBRAL-ISCHEMIA; CANINE BASILAR ARTERY; METHYL-D-ASPARTATE; L-ARGININE; COLLATERAL CIRCULATION; CEREBROVASCULAR REGULATION; PIAL ARTERIOLES; KNOCKOUT MICE; ENDOTHELIUMCardiovascular System & Cardiology; Physiology; cerebrocortical microcirculation; carotid artery occlusion; cerebrovascular regulation; pial collateral circulation; eNOS;
 Abstract: Cerebral circulation is secured by feed-forward and feed-back control pathways to maintain and eventually reestablish the optimal oxygen and nutrient supply of neurons in case of disturbances of the cardiovascular system. Using the high temporal and spatial resolution of laser-speckle imaging we aimed to analyze the pattern of cerebrocortical blood flow (CoBF) changes after unilateral (left) carotid artery occlusion (CAO) in anesthetized mice to evaluate the contribution of macrovascular (circle of Willis) vs. pial collateral vessels as well as that of endothelial nitric oxide synthase (eNOS) to the cerebrovascular adaptation to CAO. In wild-type mice CoBF reduction in the left temporal cortex started immediately after CAO, reaching its maximum (-26%) at 5-10 s. Thereafter, CoBF recovered close to the preocclusion level within 30 s indicating the activation of feed-back pathway(s). Interestingly, the frontoparietal cerebrocortical regions also showed CoBF reduction in the left (-17-19%) but not in the right hemisphere, although these brain areas receive their blood supply from the common azygos anterior cerebral artery in mice. In eNOS-deficient animals the acute CoBF reduction after CAO was unaltered, and the recovery was even accelerated compared with controls. These results indicate that 1) the Willis circle alone is not sufficient to provide an immediate compensation for the loss of one carotid artery, 2) pial collaterals attenuate the ischemia of the temporal cortex ipsilateral to CAO at the expense of the blood supply of the frontoparietal region, and 3) eNOS, surprisingly, does not play an important role in this CoBF redistribution.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Source Genre: Journal
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Publ. Info: 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA : AMER PHYSIOLOGICAL SOC
Pages: - Volume / Issue: 311 (4) Sequence Number: - Start / End Page: H972 - H980 Identifier: ISSN: 0363-6135