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  The emerging role of epigenetics in pulmonary hypertension

Gamen, E., Seeger, W., & Pullamsetti, S. S. (2016). The emerging role of epigenetics in pulmonary hypertension. EUROPEAN RESPIRATORY JOURNAL, 48(3), 903-917. doi:10.1183/13993003.01714-2015.

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 Creators:
Gamen, Elisabetta1, Author              
Seeger, Werner1, Author              
Pullamsetti, Soni Savai1, Author              
Affiliations:
1Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591698              

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Free keywords: SMOOTH-MUSCLE-CELLS; LONG NONCODING RNAS; ARTERIAL-HYPERTENSION; DNA METHYLATION; HISTONE MODIFICATIONS; ABERRANT EXPRESSION; MICRORNA EXPRESSION; VALPROIC ACID; HUMAN-DISEASE; HYPOXIARespiratory System;
 Abstract: Epigenetics is usually defined as the study of changes in phenotype and gene expression not related to sequence alterations, but rather the chemical modifications of DNA and of its associated chromatin proteins. These modifications can be acquired de novo, being inherited, and represent the way in which genome and environment interact. Recent evidence points to the involvement of epigenetic changes in the pathogenesis of pulmonary hypertension, as they can partly explain how environmental and lifestyle factors can impose susceptibility to pulmonary hypertension and can explain the phenotypic alteration and maintenance of the disease state. In this article, we review the epigenetic regulatory mechanisms that are mediated by DNA methylation, the post-translational modifications of histone tails and noncoding RNAs in the pathogenesis of pulmonary hypertension. Furthermore, pharmacological interventions aimed at epigenetic regulators/modifiers and their outcomes in different cellular and preclinical rodent models are discussed. Lastly, the remaining challenges and future directions in which to explore epigenetic-based therapies in pulmonary hypertension are discussed.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: EUROPEAN RESPIRATORY JOURNAL
Source Genre: Journal
 Creator(s):
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Publ. Info: 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND : EUROPEAN RESPIRATORY SOC JOURNALS LTD
Pages: - Volume / Issue: 48 (3) Sequence Number: - Start / End Page: 903 - 917 Identifier: ISSN: 0903-1936