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  The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

Gomez-del Arco, P., Perdiguero, E., Sofia Yunes-Leites, P., Acin-Perez, R., Zeini, M., Garcia-Gomez, A., et al. (2016). The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. CELL METABOLISM, 23(5), 881-892. doi:10.1016/j.cmet.2016.04.008.

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 Creators:
Gomez-del Arco, Pablo, Author
Perdiguero, Eusebio, Author
Sofia Yunes-Leites, Paula, Author
Acin-Perez, Rebeca, Author
Zeini, Miriam, Author
Garcia-Gomez, Antonio, Author
Sreenivasan, Krishnamoorthy1, Author              
Jimenez-Alcazar, Miguel, Author
Segales, Jessica, Author
Lopez-Maderuelo, Dolores, Author
Ornes, Beatriz, Author
Jesus Jimenez-Borreguero, Luis, Author
D'Amato, Gaetano, Author
Enshell-Seijffers, David, Author
Morgan, Bruce, Author
Georgopoulos, Katia, Author
Islam, Abul B. M. M. K., Author
Braun, Thomas1, Author              
Luis de la Pompa, Jose, Author
Kim, Johnny1, Author              
Enriquez, Jose A., AuthorBallestar, Esteban, AuthorMunoz-Canoves, Pura, AuthorMiguel Redondo, Juan, Author more..
Affiliations:
1Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591698              

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Free keywords: GENE-EXPRESSION; TRANSCRIPTIONAL MECHANISMS; LINEAGE COMMITMENT; STEM-CELLS; DIFFERENTIATION; MI-2-BETA; NURD; MITOCHONDRIA; TISSUES; GENOMECell Biology; Endocrinology & Metabolism;
 Abstract: Heart muscle maintains blood circulation, while skeletal muscle powers skeletal movement. Despite having similar myofibrilar sarcomeric structures, these striated muscles differentially express specific sarcomere components to meet their distinct contractile requirements. The mechanism responsible is still unclear. We show here that preservation of the identity of the two striated muscle types depends on epigenetic repression of the alternate lineage gene program by the chromatin remodeling complex Chd4/NuRD. Loss of Chd4 in the heart triggers aberrant expression of the skeletal muscle program, causing severe cardiomyopathy and sudden death. Conversely, genetic depletion of Chd4 in skeletal muscle causes inappropriate expression of cardiac genes and myopathy. In both striated tissues, mitochondrial function was also dependent on the Chd4/NuRD complex. We conclude that an epigenetic mechanism controls cardiac and skeletal muscle structural and metabolic identities and that loss of this regulation leads to hybrid striated muscle tissues incompatible with life.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: CELL METABOLISM
Source Genre: Journal
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Publ. Info: 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA : CELL PRESS
Pages: - Volume / Issue: 23 (5) Sequence Number: - Start / End Page: 881 - 892 Identifier: ISSN: 1550-4131