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  Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development

Ahuja, S., Dogra, D., Stainier, D. Y., & Reischauer, S. (2016). Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development. DEVELOPMENTAL BIOLOGY, 412(1), 71-82. doi:10.1016/j.ydbio.2016.02.003.

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 Creators:
Ahuja, Suchit1, Author           
Dogra, Deepika1, Author           
Stainier, Didier Y.R.1, Author           
Reischauer, Sven1, Author           
Affiliations:
1Developmental Genetics, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591697              

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Free keywords: EPITHELIAL-MESENCHYMAL TRANSITION; CANAL FORMATION; VERTEBRATE HEART; IN-VIVO; ZEBRAFISH; EXPRESSION; DIFFERENTIATION; REVEALS; CUSHION; TRANSCRIPTIONDevelopmental Biology;
 Abstract: The atrioventricular canal (AVC) connects the atrial and ventricular chambers of the heart and its formation is critical for the development of the cardiac valves, chamber septation and formation of the cardiac conduction system. Consequently, problems in AVC formation can lead to congenital defects ranging from cardiac arrhythmia to incomplete cardiac septation. While our knowledge about early heart tube formation is relatively comprehensive, much remains to be investigated about the genes that regulate AVC formation. Here we identify a new role for the basic helix-loop-helix factor Id4 in zebrafish AVC valve development and function. id4 is first expressed in the AVC endocardium and later becomes more highly expressed in the atrial chamber. TALEN induced inactivation of id4 causes retrograde blood flow at the AV canal under heat induced stress conditions, indicating defects in AV valve function. At the molecular level, we found that id4 inactivation causes misexpression of several genes important for AVC and AV valve formation including bmp4 and sppl. We further show that id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt signaling in the developing AVC endocardium. (C) 2016 Elsevier Inc. All rights reserved.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: DEVELOPMENTAL BIOLOGY
Source Genre: Journal
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Publ. Info: 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA : ACADEMIC PRESS INC ELSEVIER SCIENCE
Pages: - Volume / Issue: 412 (1) Sequence Number: - Start / End Page: 71 - 82 Identifier: ISSN: 0012-1606