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  Apicobasal polarity of brain endothelial cells

Worzfeld, T., & Schwaninger, M. (2016). Apicobasal polarity of brain endothelial cells. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36(2), 340-362. doi:10.1177/0271678X15608644.

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 Creators:
Worzfeld, Thomas1, Author              
Schwaninger, Markus, Author
Affiliations:
1Pharmacology, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591696              

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Free keywords: CEREBRAL CAVERNOUS MALFORMATIONS; MONOCARBOXYLATE TRANSPORTER MCT1; ELECTRON-MICROSCOPIC IMMUNOGOLD; CANCER RESISTANCE PROTEIN; JUNCTIONAL ADHESION MOLECULE; BARRIER GLUCOSE-TRANSPORTER; P-GLYCOPROTEIN ABCB1; BLOOD-BRAIN; LUMEN FORMATION; IN-VIVOEndocrinology & Metabolism; Hematology; Neurosciences & Neurology; Polarized secretion; Par complex; cerebral cavernous malformations; Crumbs; scribble;
 Abstract: Normal brain homeostasis depends on the integrity of the blood-brain barrier that controls the access of nutrients, humoral factors, and immune cells to the CNS. The blood-brain barrier is composed mainly of brain endothelial cells. Forming the interface between two compartments, they are highly polarized. Apical/luminal and basolateral/abluminal membranes differ in their lipid and (glyco-) protein composition, allowing brain endothelial cells to secrete or transport soluble factors in a polarized manner and to maintain blood flow. Here, we summarize the basic concepts of apicobasal cell polarity in brain endothelial cells. To address potential molecular mechanisms underlying apicobasal polarity in brain endothelial cells, we draw on investigations in epithelial cells and discuss how polarity may go awry in neurological diseases.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 23
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000371299800008
DOI: 10.1177/0271678X15608644
 Degree: -

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Title: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA : SAGE PUBLICATIONS INC
Pages: - Volume / Issue: 36 (2) Sequence Number: - Start / End Page: 340 - 362 Identifier: ISSN: 0271-678X