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  Analysis of XFEL serial diffraction data from individual crystalline fibrils

Wojtas, D. H., Ayyer, K., Liang, M., Mossou, E., Romoli, F., Seuring, C., et al. (2017). Analysis of XFEL serial diffraction data from individual crystalline fibrils. IUCrJ, 4, 795-811. doi:10.1107/S2052252517014324.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-D80F-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-D810-9
Genre: Journal Article

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This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
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2017
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https://dx.doi.org/10.1107/S2052252517014324 (Publisher version)
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 Creators:
Wojtas, D. H.1, Author
Ayyer, K.2, Author
Liang, M.3, Author
Mossou, E.4, 5, Author
Romoli, F.6, Author
Seuring, C.2, Author
Beyerlein, K. R.2, Author
Bean, R. J.7, Author
Morgan, A. J.2, Author
Oberthuer, D.2, Author
Fleckenstein, H.2, Author
Heymann, M.2, 8, Author
Gati, C.2, Author
Yefanov, O.2, Author
Barthelmess, M.2, Author
Ornithopoulou, E.9, Author
Galli, L.2, Author
Paulraj, L. X.2, 10, Author              
Ling, W. L.11, Author
Frank, M.12, Author
Yoon, C. H.3, AuthorWhite, T. A.2, AuthorBajt, S.13, AuthorMitraki, A.9, AuthorBoutet, S.3, AuthorAquila, A.3, AuthorBarty, A.2, AuthorForsyth, V. T.4, 5, AuthorChapmanb, H. N.2, 14, 15, AuthorMillanea, R. P.1, Author more..
Affiliations:
1Department of Electrical and Computer Engineering, University of Canterbury, Christchurch, New Zealand, ou_persistent22              
2Centre for Free-Electron Laser Science, DESY, ou_persistent22              
3Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, ou_persistent22              
4Institut Laue-Langevin, Grenoble, ou_persistent22              
5Faculty of Natural Sciences, Keele University, England, ou_persistent22              
6European Synchrotron Radiation Facility, Grenoble, ou_persistent22              
7European XFEL GmbH, Hamburg, ou_persistent22              
8Max Planck Institute of Biochemistry, Martinsried, ou_persistent22              
9Department of Materials Science and Technology, University of Crete and IESL/FORTH, Crete, ou_persistent22              
10International Max Planck Research School for Ultrafast Imaging & Structural Dynamics (IMPRS-UFAST), Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_2266714              
11Université Grenoble Alpes, Grenoble,, ou_persistent22              
12Lawrence Livermore National Laboratory, Livermore, ou_persistent22              
13Photon Science, DESY, Hamburg, ou_persistent22              
14Department of Physics, University of Hamburg, ou_persistent22              
15Centre for Ultrafast Imaging, University of Hamburg, ou_persistent22              

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Free keywords: serial crystallography; coherent X-ray diffractive imaging (CXDI); single particles; molecular orientation determination; crystalline fibrils; amyloid
 Abstract: Serial diffraction data collected at the Linac Coherent Light Source from crystalline amyloid fibrils delivered in a liquid jet show that the fibrils are well oriented in the jet. At low fibril concentrations, diffraction patterns are recorded from single fibrils; these patterns are weak and contain only a few reflections. Methods are developed for determining the orientation of patterns in reciprocal space and merging them in three dimensions. This allows the individual structure amplitudes to be calculated, thus overcoming the limitations of orientation and cylindrical averaging in conventional fibre diffraction analysis. The advantages of this technique should allow structural studies of fibrous systems in biology that are inaccessible using existing techniques.

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Language(s): eng - English
 Dates: 2017-06-092017-10-042017-11
 Publication Status: Published online
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1107/S2052252517014324
 Degree: -

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Title: IUCrJ
Source Genre: Journal
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Publ. Info: Chester CH1 2HU, England : International Union of Crystallography (IUCr)
Pages: - Volume / Issue: 4 Sequence Number: - Start / End Page: 795 - 811 Identifier: ISSN: 2052-2525
CoNE: /journals/resource/2052-2525