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  DNA-based construction at the nanoscale: emerging trends and applications

Paulraj, L. X., & Chandrasekaran, A. R. (2018). DNA-based construction at the nanoscale: emerging trends and applications. Nanotechnology, 29(6): 062001. doi:10.1088/1361-6528/aaa120.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-D596-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-D597-4
Genre: Journal Article

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Xavier_2018_Nanotechnology_29_062001.pdf (Publisher version), 8MB
 
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https://dx.doi.org/10.1088/1361-6528/aaa120 (Publisher version)
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 Creators:
Paulraj, L. X.1, 2, 3, Author              
Chandrasekaran, A. R.4, Author
Affiliations:
1International Max Planck Research School for Ultrafast Imaging & Structural Dynamics (IMPRS-UFAST), Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society, ou_2266714              
2Center for Free Electron Laser Science, Deutsches Elektronen-Synchrotron (DESY), ou_persistent22              
3Department of Physics, University of Hamburg, ou_persistent22              
4Confer Health, Inc., Charlestown, ou_persistent22              

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Free keywords: DNA origami, DNA nanotechnology, programmable matter, cryo-EM, XFEL, super-resolution, structural dynamics
 Abstract: The field of structural DNA nanotechnology has evolved remarkably—from the creation of artificial immobile junctions to the recent DNA–protein hybrid nanoscale shapes—in a span of about 35 years. It is now possible to create complex DNA-based nanoscale shapes and large hierarchical assemblies with greater stability and predictability, thanks to the development of computational tools and advances in experimental techniques. Although it started with the original goal of DNA-assisted structure determination of difficult-to-crystallize molecules, DNA nanotechnology has found its applications in a myriad of fields. In this review, we cover some of the basic and emerging assembly principles: hybridization, base stacking/shape complementarity, and protein-mediated formation of nanoscale structures. We also review various applications of DNA nanostructures, with special emphasis on some of the biophysical applications that have been reported in recent years. In the outlook, we discuss further improvements in the assembly of such structures, and explore possible future applications involving super-resolved fluorescence, single-particle cryo-electron (cryo-EM) and x-ray free electron laser (XFEL) nanoscopic imaging techniques, and in creating new synergistic designer materials.

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Language(s): eng - English
 Dates: 2017-11-142017-10-082017-12-122018-01-102018-02-09
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1088/1361-6528/aaa120
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Project name : PLX thanks advisors H N Chapman and N C Seeman for inducting into DNA nanotechnology and for stimulating discussions and acknowledges the support of the International Max-Planck Research School for Ultrafast Imaging and Structural Dynamics ( IMPRS-UFAST ) of the Max-Planck Society, graduate student training program of the Linac Coherent Light Source ( LCLS, Stanford ) , the European Research Council — Frontiers in Attosecond X-ray Science: Imaging and Spectroscopy ( AXSIS ) , the Human Frontiers Science Program, and the Helmholtz Association.
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Title: Nanotechnology
Source Genre: Journal
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Publ. Info: Bristol, UK : IOP Pub.
Pages: - Volume / Issue: 29 (6) Sequence Number: 062001 Start / End Page: - Identifier: ISSN: 0957-4484
CoNE: /journals/resource/954925577042