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  Photolysis of parabens using medium-pressure mercury lamps: Toxicity effects in MCF7, BAlb/c 3T3 cells and Ceriodaphnia dubia

Gomes, F. E. R., Bergo, P. L. S., Trapp, M. A., Spadoto, M., Galinaro, C. A., Rodrigues-Filho, E., et al. (2018). Photolysis of parabens using medium-pressure mercury lamps: Toxicity effects in MCF7, BAlb/c 3T3 cells and Ceriodaphnia dubia. Chemosphere, 208, 325-334. doi:10.1016/j.chemosphere.2018.05.135.

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Gomes, Francisco E. R., Author
Bergo, Patricia L. S., Author
Trapp, Marilia A.1, Author              
Spadoto, Mariangela, Author
Galinaro, Carlos A., Author
Rodrigues-Filho, Edson, Author
Leitao, Andrei, Author
Tremiliosi-Filho, Germano, Author
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1External Organizations, ou_persistent22              

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 Abstract: Degradation studies of the propylparaben (PrP), butylparaben (BuP) and of the propylparaben-butylparaben mixture (PrP-BuP) in deionized water and surface river water was investigated as a function of pH and initial concentration of the reactants using a medium-pressure mercury lamp. The photolysis of parabens (concentration ranging from 5 to 30 mg L−1) followed apparent pseudo-first-order kinetics, with rate constants (k) in deionized water and surface river water changed from 1.80 × 10−1 to 3.68 × 10−2 min−1 and 1.43 × 10−1 to 1.45 × 10−2 min−1, respectively. Degradation reaction was faster at pH 5 in comparison with pH 7 or 11. The photolysis of parabens was greater than 91%, with low mineralization (26.15%) observed in acidic medium after 95 min. Analysis by chromatography coupled to mass spectrometry (LC-MS/MS) showed that only one product was generated during the degradation reaction and has UV bands similar to 3,4-dihydroxybenzoic acid. Estrogenic activity tests showed that non-degraded parabens stimulated the growth of breast adenocarcinoma (MCF-7) cells and this effect was evaluated after the photolysis. Cytotoxicity assays using fibroblasts cells (Balb/C 3T3 clone A31) indicated that the parental compounds and degradation products were not cytotoxic. On the contrary, non-degraded parabens were toxic to Ceriodaphnia dubia, but the product of photolysis was not. Overall, the photolytic method presented was able to degrade these parabens providing safe and non-estrogenic reaction product.

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 Dates: 2018-05-232018-05-282018
 Publication Status: Published in print
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 Identifiers: Other: EXT566
DOI: 10.1016/j.chemosphere.2018.05.135
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Title: Chemosphere
  Other : Chemosphere
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 208 Sequence Number: - Start / End Page: 325 - 334 Identifier: ISSN: 0045-6535
CoNE: https://pure.mpg.de/cone/journals/resource/974392605047