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  X-ray diffraction evidence for alpha-helical coiled-coils in native muscle

Cohen, C., & Holmes, K. C. (1963). X-ray diffraction evidence for alpha-helical coiled-coils in native muscle. Journal of Molecular Biology (London), 6(5), 423-432. doi:10.1016/S0022-2836(63)80053-4.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-DB6C-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-DB6D-F
Genre: Journal Article
Alternative Title : X-ray diffraction evidence for helical coiled-coils in native muscle

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 Creators:
Cohen, Carolyn, Author
Holmes, Kenneth C.1, 2, 3, Author           
Affiliations:
1Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497712              
2Muscle Research, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497731              
3Protein Cristallography XDS, Max Planck Institute for Medical Research, Max Planck Society, Jahnstrasse 29, 69120 Heidelberg, DE, ou_1497735              

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 Abstract: An improved α-diagram has been obtained from a native molluscan “catch” muscle (the anterior byssal retractor muscle of Mytilus edulis). The most striking aspect of the diagram is a strong near-equatorial layer line at about 89 Å. The 5·1 Å spacing is meridional. These features are accounted for by a coiled-coil α-helical structure. Computations indicate that the best fit is obtained with a two-chain structure when various types of disorder are assumed. A possible model is described having a densely packed hydrophobic region between the chains, and most of the polar groups pointing out into the solvent. An implication of the coiled-coil structure is that the α-helix in proteins requires stabilization by side-chain interactions.

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Language(s): eng - English
 Dates: 1962-06-201963-02-041963-05-01
 Publication Status: Issued
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/S0022-2836(63)80053-4
URI: https://www.ncbi.nlm.nih.gov/pubmed/14022021
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Title: Journal of Molecular Biology (London)
  Other : J Mol Biol
Source Genre: Journal
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Publ. Info: London : Academic Press
Pages: - Volume / Issue: 6 (5) Sequence Number: - Start / End Page: 423 - 432 Identifier: ISSN: 0022-2836
CoNE: https://pure.mpg.de/cone/journals/resource/954922646042