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  Cytosine-5-methyltransferases add aldehydes to DNA.

Liutkevičiūtė, Z., Lukinavicius, G., Masevičius, V., Daujotytė, D., & Klimašauskas, S. (2009). Cytosine-5-methyltransferases add aldehydes to DNA. Nature Chemical Biology, 5(6), 400-402. doi:10.1038/nchembio.172.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-DFCF-C Version Permalink: http://hdl.handle.net/21.11116/0000-0001-DFD3-6
Genre: Journal Article

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Liutkevičiūtė, Z., Author
Lukinavicius, G.1, Author              
Masevičius, V., Author
Daujotytė, D., Author
Klimašauskas, S., Author
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1Laboratory of Chromatin Labeling and Imaging, Max Planck Institute for Biophysical Chemistry, Max Planck Society, ou_2616691              

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 Abstract: Targeted methylation of cytosine residues by S-adenosylmethionine–dependent DNA methyltransferases modulates gene expression in vertebrates. Here we show that cytosine-5-methyltransferases catalyze reversible covalent addition of exogenous aliphatic aldehydes to their target residues in DNA, thus yielding corresponding 5-α-hydroxyalkylcytosines. Such atypical enzymatic reactions with non-cofactor-like substrates open new ways for sequence-specific derivatization of DNA and demonstrate enzymatic exchange of 5-hydroxymethyl groups on cytosine in support of an oxidative mechanism of DNA demethylation.

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Language(s): eng - English
 Dates: 2009-05-102009-06
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/nchembio.172
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Title: Nature Chemical Biology
Source Genre: Journal
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Pages: - Volume / Issue: 5 (6) Sequence Number: - Start / End Page: 400 - 402 Identifier: -