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  Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia

Tucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., et al. (2018). Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia. Science, 361(6401), 511-516. doi:10.1126/science.aar8486.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-E132-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-E3A2-7
Genre: Journal Article

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Tucci, Serena1, Author
Vohr, Samuel H., Author
McCoy, Rajiv C., Author
Vernot, Benjamin, Author
Robinson, Matthew R., Author
Barbieri, Chiara1, Author              
Nelson, Brad J., Author
Fu, Wenqing, Author
Purnomo, Gludhug A., Author
Sudoyo, Herawati, Author
Eichler, Evan E., Author
Barbujani, Guido, Author
Visscher, Peter M., Author
Akey, Joshua M., Author
Green, Richard E., Author
Affiliations:
1Linguistic and Cultural Evolution, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074311              

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 Abstract: Flores Island in Indonesia has a long history of hominin occupation, including by the extinct Homo floresiensis and a more recent settlement by modern humans. Furthermore, Flores has an extant population of pygmy humans, and H. floresiensis exhibited a diminutive adult size relative to other hominins. Tucci et al. examined genetic variation among 32 individuals, including 10 sequenced genomes, from a population of pygmies living close to the cave where H. floresiensis remains were discovered. These individuals exhibit signatures of polygenic selection explaining the short stature and have genomic content from both Neanderthals and Denisovans, but no additional archaic lineages. Thus, restricted height is under selection at this location and has evolved independently at least twice in hominins.Science, this issue p. 511Flores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores.

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Language(s): eng - English
 Dates: 2018-08-03
 Publication Status: Published online
 Pages: 8
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.aar8486
Other: shh1040
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Title: Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 361 (6401) Sequence Number: - Start / End Page: 511 - 516 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1