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  Alcohol consumption is positively associated with fasting serum ghrelin in non-dependent adults: Results from the population-based LIFE-Adult-Study

Wittekind, D. A., Kratzsch, J., Mergl, R., Enzenbach, C., Witte, A. V., Villringer, A., et al. (2018). Alcohol consumption is positively associated with fasting serum ghrelin in non-dependent adults: Results from the population-based LIFE-Adult-Study. Psychoneuroendocrinology, 97, 143-148. doi:10.1016/j.psyneuen.2018.07.021.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-E1C0-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A288-C
Genre: Journal Article

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 Creators:
Wittekind, Dirk Alexander1, Author
Kratzsch, Jürgen2, Author
Mergl, Roland1, Author
Enzenbach, Cornelia3, Author
Witte, A. Veronica4, Author              
Villringer, Arno4, Author              
Kluge, Michael1, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
2Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
3Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Ghrelin; Alcohol consumption; Alcohol dependence; Social drinking
 Abstract: Background: Animal experiments and studies in alcohol dependent patients indicate that ghrelin signaling in the brain is causally involved in the regulation of alcohol reward and intake. Increasing ghrelin levels enhances alcohol craving and intake, blocking ghrelin receptors abolishes these effects. If ghrelin is also involved in non-dependent alcohol consumption in humans, though, remains unknown. The aim was therefore to investigate the relationship between ghrelin serum levels and alcohol consumption in a large population-based sample. Methods: Total ghrelin was determined after an overnight fast in 1666 subjects participating in a population-based cross-sectional study (‘LIFE’) including 10,000 adults. 1521 subjects were included in this analysis. Alcohol consumption was assessed using a food frequency questionnaire (FFQ). Multiple linear regression analyses and extreme group comparisons testing for statistical differences of alcohol consumption between the highest and lowest quartile according to ghrelin levels were performed. Results: Alcohol consumption was positively associated with serum ghrelin; total sample: β = 0.003, p = 0.002; men: β = 0.005, p = 0.023; women: β = 0.002, p = 0.007, adjusted for age, BMI and smoking status. Mean alcohol consumption in men/women belonging to the highest quartile of serum ghrelin levels (men: 21.5 (21.1) g/day; women: 7.5 (11.4) g/day) was considerably higher than in those belonging to the lowest quartile (men: 16.5 (19.3) g/day p < 0.002; women: 4.59 (10.7) g/day p = 0.0001). Conclusion: This is the first study showing that alcohol consumption is positively associated with serum ghrelin in a population-based sample. The study provides an initial indication that ghrelin is also involved in the regulation of alcohol consumption in non-dependent subjects.

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Language(s): eng - English
 Dates: 2018-07-032018-05-052018-07-132018-07-182018-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.psyneuen.2018.07.021
PMID: 30029157
Other: Epub 2018
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Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
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Funding organization : European Union (EU)
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Funding program : European Social Fund (ESF)
Funding organization : European Commission (EC)
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Funding program : European Regional Development Fund (ERDF)
Funding organization : European Commission (EC)
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Funding program : -
Funding organization : Free State of Saxony

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Title: Psychoneuroendocrinology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 97 Sequence Number: - Start / End Page: 143 - 148 Identifier: ISSN: 0306-4530
CoNE: https://pure.mpg.de/cone/journals/resource/954925514499