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  Near-infrared spectroscopy patterns of cortical activity during gait in Parkinson’s disease patients treated with DBS STN

Klempir, O., Krupička, R., Mehnert, J., Čejka, V., Peterová, K., Plaňanská, E., et al. (2018). Near-infrared spectroscopy patterns of cortical activity during gait in Parkinson’s disease patients treated with DBS STN. Gait & Posture, 65(Suppl. 1): P 024, 273-275. doi:10.1016/j.gaitpost.2018.06.181.

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 Creators:
Klempir, Ondrej 1, Author
Krupička, R. 1, Author
Mehnert, Jan2, Author              
Čejka, V. 1, Author
Peterová, K. 3, Author
Plaňanská, E. 3, Author
Brožová, H. 3, Author
Růžička, E.3, Author
Szabó, Z. 1, Author
Jech, R. 3, Author
Affiliations:
1Department of Biomedical Informatics, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              

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Free keywords: Near infrared spectroscopy; Parkinson’s disease; Gait; Deep brain stimulation; Neuromodulation
 Abstract: Disorders of gait seriously affect the functional state and quality of life of patients with Parkinson’s disease (PD). Impaired brain function underlies disorders of movement control in PD, however functional brain imaging with magnetic resonance (fMRI) is not feasible during gait. Near-Infrared Spectroscopy (NIRS) is a portable imaging method for measuring brain activity. It uses low-energy optical radiation to detect local changes of (de)oxyhemoglobin concentration in the cerebral cortex, like a fMRI. We included 8 patients with advanced PD chronically treated with DBS STN. Brain activity was recorded with the NIRSport. Gait was examined in 10 cycles, during which the active and resting phases alternated. Changes in oxyhemoglobin concentration were calculated from the native NIRS signal using a modified transformation of the Lambert-Beer Law. The signals were filtered in the 0.015–0.3 Hz band and the least-squares algorithm was fitted with the HRF function for each cycle separately, from which the median was finally calculated. The activity of the motor cortex was significantly higher during gait in the OFF compared to ON state (p = 0.02). In contrast, in other regions no differences were found. A higher motor cortex activity shown in the DBS OFF compared to ON state may reflect the impairment of gait control in PD. In general terms, the present study demonstrates the potential utility of the NIRS method in detecting functional changes of the brain during gait in patients with PD.

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Language(s): eng - English
 Dates: 2018-07-172018-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.gaitpost.2018.06.181
PMID: 30037751
 Degree: -

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Title: Gait & Posture
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 65 (Suppl. 1) Sequence Number: P 024 Start / End Page: 273 - 275 Identifier: ISSN: 0966-6362
CoNE: https://pure.mpg.de/cone/journals/resource/0966-6362