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  The genetic prehistory of the Andean highlands 7,000 Years BP though European contact

Lindo, J., Haas, R., Hofman, C., Apata, M., Moraga, M., Verdugo, R., et al. (2018). The genetic prehistory of the Andean highlands 7,000 Years BP though European contact. bioRxiv. doi:10.1101/381905.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-E50B-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-E526-2
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 Creators:
Lindo, John, Author
Haas, Randall, Author
Hofman, Courtney, Author
Apata, Mario, Author
Moraga, Mauricio, Author
Verdugo, Ricardo, Author
Watson, James T, Author
Llave, Carlos, Author
Witonsky, David, Author
Pacheco, Enrique, Author
Villena, Mercedes, Author
Soria, Rudy, Author
Beall, Cynthia, Author
Warinner, Christina G.1, Author              
Novembre, John, Author
Aldenderfer, Mark, Author
Di Rienzo, Anna, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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 Abstract: The peopling of the Andean highlands above 2500m in elevation was a complex process that included cultural, biological and genetic adaptations. Here we present a time series of ancient whole genomes from the Andes of Peru, dating back to 7,000 calendar years before present (BP), and compare them to 64 new genome-wide genetic variation datasets from both high and lowland populations. We infer three significant features: a split between low and high elevation populations that occurred between 9200-8200 BP; a population collapse after European contact that is significantly more severe in South American lowlanders than in highland populations; and evidence for positive selection at genetic loci related to starch digestion and plausibly pathogen resistance after European contact. Importantly, we do not find selective sweep signals related to known components of the human hypoxia response, which may suggest more complex modes of genetic adaptation to high altitude.

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Language(s): eng - English
 Dates: 2018-07-31
 Publication Status: Published online
 Pages: 20
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1101/381905
Other: shh1047
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Title: bioRxiv
Source Genre: Journal
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Publ. Info: Cold Spring Harbor Laboratory
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