English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Effects of chronic alcoholic disease on magnocellular and parvocellular hypothalamic neurons in men

Sivukhina, E. V., Dolzhikov, A. A., Morozov, I. E., Jirikowski, G. F., & Grinevich, V. (2006). Effects of chronic alcoholic disease on magnocellular and parvocellular hypothalamic neurons in men. Hormone and metabolic research, 38(6), 382-390. doi:10.1055/s-2006-944522.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0001-E566-A Version Permalink: http://hdl.handle.net/21.11116/0000-0001-E567-9
Genre: Journal Article

Files

show Files
hide Files
:
HormMetabRes_38_2006_382.pdf (Any fulltext), 893KB
 
File Permalink:
-
Name:
HormMetabRes_38_2006_382.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, Heidelberg; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
https://doi.org/10.1055/s-2006-944522 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Sivukhina, Elena V., Author
Dolzhikov, A. A., Author
Morozov, Iu. E., Author
Jirikowski, Gustav F., Author
Grinevich, Valery1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: Vasopressin; oxytocin; corticotrophin-releasing hormone; human; alcoholic disease
 Abstract: Although numerous data showing severe morphological impairment of magnocellular and parvocellular hypothalamic neurons due to chronic alcoholic consumption have been gathered from animal experiments, only one study (Harding et al., 1996) was performed on POST MORTEM human brain. This study showed a reduction in the number of vasopressin (VP)-immunoreactive neurons in the supraoptic (SON) and paraventricular (PVN) nuclei, but did not provide any data regarding the effect of chronic alcohol intake on human parvocellular neurons. In order to assess whether the changes observed in the animal model also occur in humans and provide a structural basis for the results of clinical tests, we performed immunohistochemical and morphometric analysis of magnocellular (VP and oxytocin, OT) and parvocellular (corticotropin-releasing hormone, CRH) neurons in post-mortem brains of patients afflicted with chronic alcoholic disease. We analyzed 26-male alcoholics and 22 age-matched controls divided into two age groups--"young" (< 40 yr) and "old" (> 40 yr). Hypothalamic sections were stained for OT, VP, and CRH. The analysis revealed: 1) decrease in VP-immunoreactivity in the SON and PVN as well as OT-immunoreactivity in the SON in alcoholic patients; 2) increase in OT-immunoreactivity in the PVN; 3) increase in CRH-immunoreactivity in parvocellular neurons in the PVN. Furthermore, the proportion of cells containing CRH and VP was increased in alcoholics. These findings indicate that chronic alcohol consumption does indeed impair the morphology of magnocellular neurons. The enhancement of CRH-immunoreactivity and increased co-production of CRH and VP in parvocellular neurons may be due to a decline in glucocorticoid production, implied by the hypoplasic impairment of adrenal cortex we observed in alcoholics during the course of this study.

Details

show
hide
Language(s): eng - English
 Dates: 2005-11-302006-02-202006-07-062006-06-01
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Hormone and metabolic research
  Alternative Title : Horm Metab Res
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Stuttgart : Thieme, Germany
Pages: - Volume / Issue: 38 (6) Sequence Number: - Start / End Page: 382 - 390 Identifier: ISSN: 0018-5043