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  Magnesium as an intrinsic component of human otoconia

Walther, L. E., Wulfes, J., Blödow, A., & Kniep, R. (2018). Magnesium as an intrinsic component of human otoconia. Acta Oto-Laryngologica, 0(0), 1-4. doi:10.1080/00016489.2018.1467572.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-E73F-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-E742-0
Genre: Journal Article

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 Creators:
Walther, Leif Erik1, Author
Wulfes, Jana2, Author              
Blödow, Alexander1, Author
Kniep, Rüdiger3, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Inorganic Chemistry, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863425              
3Rüdiger Kniep, Inorganic Chemistry, Max Planck Institute for Chemical Physics of Solids, Max Planck Society, ou_1863437              

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 Abstract: AbstractObjectives: To investigate morphology changes of artificial otoconia (CGC) in the presence of magnesium during growth under in vitro conditions.Methods: Investigating human otoconia by environmental scanning electron microscope and determining their magnesium content by energy-dispersive X-ray microanalysis (EDX). Comparing structural and morphological data of human and artificial otoconia (CGC, Ca1Mg0) without and with magnesium substitution (Ca1-xMgx).Results: EDX- and X-ray data reveals that the inorganic component in human otoconia consists of calcite containing a minor amount of magnesium substitution (Ca1-xMgx). CGC containing magnesium (length 397.0 ± 146.4 µm, diameter 325.6 ± 100.1 µm) are slimmer and significantly smaller (p < .01) than pure CGC (length 548.6 ± 160 µm, diameter 373.0 ± 110.4 µm) and reveal a significant influence on the final morphology. The length/diameter ratio is significantly higher by incorporation of magnesium into CGC (1.84 ± 0.25 µm versus 1.48 ± 0.11 µm in pure CGC, p < .01), which brings the overall shape to a close relationship with human otoconia (1.98 ± 0.08 µm).Conclusions: Magnesium is an intrinsic component of human otoconia by partial substitution of calcium in the calcite crystal structure (Ca1-xMgx) and affects the development of the shape of artificial otoconia (calcite gelatin composites, CGC).

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Language(s): eng - English
 Dates: 2018-05-152018-05-15
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1080/00016489.2018.1467572
BibTex Citekey: doi:10.1080/00016489.2018.1467572
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Title: Acta Oto-Laryngologica
Source Genre: Journal
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Publ. Info: Information Healthcare
Pages: - Volume / Issue: 0 (0) Sequence Number: - Start / End Page: 1 - 4 Identifier: CoNE: /journals/resource/0001-6489