English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Iron-related gene expression associated with magnetic susceptibility reductions: Application to the pathophysiology of a movement disorder population

Kanaan, A. S., Anwander, A., Metere, R., Schäfer, A., Schlumm, T., Near, J., et al. (2018). Iron-related gene expression associated with magnetic susceptibility reductions: Application to the pathophysiology of a movement disorder population. In Proceedings of the 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM).

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0001-EA23-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-6493-A
Genre: Meeting Abstract

Files

show Files

Locators

show
hide
Locator:
https://www.ismrm.org/18/program_files/PP04.htm (Abstract)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Kanaan, Ahmad S.1, Author           
Anwander, Alfred2, Author           
Metere, Riccardo1, Author           
Schäfer, Andreas3, Author           
Schlumm, Torsten1, Author           
Near, Jamie3, Author
Bilgic, Berkin3, Author
Müller-Vahl, Kirsten3, Author
Möller, Harald E.1, Author                 
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
3External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: We employ a genetic-imaging approach to examine the underlying genetic basis of magnetic susceptibility reductions at a major locus of pathophysiology in Gilles de la Tourette syndrome (GTS). Voxel-wise statistical differences of motor-striatal susceptibility exhibited significant associations with the expression profile of iron-related gene-sets extracted from the Allen Human Brain Atlas, thus suggesting that the expression of iron-related genes coincides with patterns of susceptibility reductions in GTS. This work supports previous studies relating magnetic susceptibility to brain iron and provides an example of an analytic strategy in which valuable insights can be gleaned by exploring associations between gene-expression and image-derived phenotypes.

Details

show
hide
Language(s): eng - English
 Dates: 2018-06-162018-06-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: 0222 Start / End Page: - Identifier: -